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Synergistic Effects of Vsncomycin, Penicillin, and Gentamicin against Vancomycin-Resistant Enterococci

Other Title
Vancomycin 내성 장구균에 대한 Vancomycin, Penicillin 및 Gentamicin의 병용효과
이, 위교; 이, 선민; 곽, 연식
Taehan Hwahak Yopŏp Hakhoe chi, 15(2):243-250, 1997
Journal Title
Taehan Hwahak Yopŏp Hakhoe chi; The journal of the Korean Society for Chemotherapy; 대한화학요법학회지
Background : Because of the resistance that enterococci aiready exhibit to a variety of

antimicrobial agents, the emergence of vancomycin resistance is troublesome. The

combined regimes may offer a treatment for patients infected with vancomycin-resistant

enterooocci. We examined the antibiotic synergistic killing of clinical isolates of

vancomycih-resistant enterococci belonging to genotypic resistance classes A, B, and C.

Methods : Nine strains of vancomycin-resistant enterococci and 2 strains of

vancomycin-susceptible enterococci were utilized in this study. MICs were determined

by agar dilution method. Synergistic inhibition of growth was assessed by addition

vancomycin(8㎍/mL), penicillin(2㎍/mL), gentamicin(1㎍/mL), or combinations of these

antibiotics to cultures in the early logarlthaic phase of growth. Synergy was defined as

a decrease in CFU/mL by at least 2 log10 after 24 h compared with the effect of the

most active single agent.

Results : Vancomycin-penicillin-gentamicini and vancomycin-penicillin resulted in 2 or

more logs of killing above that the most effective single agent for all VanA and VanB

strains. All VanC strains were resistant to any antibiotics combination.

Conclusion : Triple combination therapy arid vancomycin plus penicillin regimen may

be effective for the treatment of infections caused by vancomycin-resistant enterococci

belonging to genotypic classes VanA and VanB. Further studios are needed for the new

therapeutic regimen agaist VanC strains.
Vancomycin-resistant enterococciVancomycinPenicillinGentamicin
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Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
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