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Biodistribution of Intrasplenically Transplanted Hepatocytes in the Rat

Other Title
백서의 급, 만성 간부전 모델에서 비장에 이식된 간세포의 초기 장기별 분포에 관한 연구
김, 욱환; 박, 혜리; 한, 상욱; 왕, 희정; 김, 명욱; 이, 재호; 진, 윤미; 김, 병호
Taehan Oekwa Hakhoe, 54(6):772-779, 1998
Journal Title
Taehan Oekwa Hakhoe; 대한외과학회지
Liver failure still constitutes a major cause of morbidity and death in patients with

liver disease. Various potential treatments have been discussed to reduce liver

failure-induced deaths. Recently, interest in hepatocyte transplantation(HT) has markedly

increased, and HT has been tried for the treatment of liver failure. Both experimental

and clinical data indicate that HT may be beneficial both for the support of an acutely

devastated liver and for the correction of genetic disorders resulting in states of

metabolic deficiency. For this purpose, the location of the HT has been suggested as a

critical point. Therefore, we tried to study the biodistribution of hepatocytes in acute and

chronic liver failure model in rats at 2 hours and 24 hours after the injection of

125I-labeled hepatocytes into the spleen. A ninety percent partial

hepatectomy model and a dimethylnitrosamine-induced liver-cirrhosis model were used

as the acute and chronic liver-failure models respectively. An SV-40 T-transfected

immotilized cell line named L2A2 was transplanted

intrasplenically. The biodistribution of the transplanted hepatocytes was similar in both

the acute and the chronic liver-failure groups. In both groups, the biodistribution studies

at 2 hours and 24 hours after intrasplenic transplantation demonstrated that the

hepatocytes were localized predominantly in the spleen. However, intrasplenic retention

of the transplanted hepatocytes progressively decreased with time. We conclude that

methods for preventing the progressive loss of intrasplenic transplanted hepatocytes

should be investigated.
Hepatocyte transplantationLiver failureDistributionSpleen
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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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