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Role of Hepatocyte Growth Factor, Met, and E-cadherin in the Progression of Gastric Carcinomas

Other Title
위암의 진행과 간세포성장인자(HGF), Met 그리고 E-cadherin 발현간의 상호관계
Authors
한, 상욱; 김, 욱환; 조, 용관; 김, 명욱; 주, 희재; 이, 재호
Citation
Taehan Oekwa Hakhoe, 55(1):53-64, 1998
Journal Title
Taehan Oekwa Hakhoe; 대한외과학회지
ISSN
1226-0053
Abstract
Hepatocyte growth factor (HGF) is a glycoprotein secreted from stromal fibroblasts

which bind to the transmembrane Met receptor This receptor is expressed from a

variety of tumors, including gastric carcinomas. To look for a possible paracrine loop

between gastric cancer cells and their surrounding fibroblasts in a gastric carcinoma, the

effect of HGF on the morphology and expression of the cell-adhesion molecule

E-cadherin was examined using fifty resected gastric carcinomas. The expression of

Met and E-cadherin in primary gastric carcinoma was examined using

immunohistochemical staining. The level of HGF in the tumor extracts was determined

by using an Immunis HGF EIA kit (Institute of Immunology). The levels of HGF in the

tumor extracts correlated significantly with the progression of the tumor stage (p<0.05).

The mean level of HGF was significantly higher in the tumors of an undifferentiated

type than in those of a differentiated type (p<0.05). Eighty-two percent (82%) of the

tumors showed increased Met expression, but no significant correlation was found

between Met expression and tumor progression or differentiation. Twenty-six (52%)

tumors revealed a preserved E-cadherin expression similar to that of a normal gastric

mucosa. Abnormal E-cadherin expression was found in twenty-four tumors (48%).

There was a significant correlaticm between the degree of E-cadherin expression and

the progression and differentiation of the tumor. The level of HGF in a tumor with

cytoplasmic E-cadherin expression was significantly higher than that with membranous

E-cadherin expression. In conclusion: we can conclude that HGF has the ability to

modulate E-cadherin expression and induce intracellular translocation of E-cadherin in

gastric carcinomas.
Keywords
Hepatocyte growth factorMetE-cadherinGastric carcinomaDifferentiation
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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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