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Role of Serum Hepatocyte Growth Factor in Gastric Cancer Patients
|dc.description.abstract||Background : Hepatocyte growth factor (HGF) was first identified as a potent
stimulator of hepatocyte growth. Later, it was shown that HGF and promote cell
motility and cell proliferation in tumor cells as well as in endothelial cells. To look for
the significance of HGF in patients with gastric cancer, we measured the serum levels
of HGF in gastric cancer patients and followed the levels of HGF after resection of the
Methods : The serum levels of HGF were determined by using an Immunis HGF
ELISA kit. The serum levels of CEA, CA125, and CA19-9 in the same serum sample
were examined using the ELISA method.
Results : The mean levels of serum HGF in 212 healthy control subjects, 105 patients
with primary gastric cancer, 54 patients after resections of the tumors, and 13 patients
with recurrent gastric cancer were 0.20±0.07 ng/ml, 0.33±0.26 ng/ml, 0.20±0.19 ng/ml,
and 0.58±0.26 ng/ml respectively. Of the 105 patients with primary gastric cancer, 35
(33.3%) showed an abnormal increase in the serum level of HGF. The increased HGF
levels were significantly associated with the degree of tumor invasion, nodal metastasis,
distant metastasis and stage. Also the HGF levels increased significantly with increasing
tumor size. The HGF levels decreased to normal levels by one month after the
resections of the tumors. The HGF levels in recurrent gastric cancer patients were
significantly higher than those of nonrecurrent patients after resections of the tumors.
Among several tumor markers including CEA, CA125, and CA19-9, HGF was revealed
to be the one most correlated with the occurrence of gastric cancer.
Conclusions : The serum levels of HGF were significantly correlated with the
aggressiveness of the tumors, suggesting that HGF might play an important role in the
tumor progression of gastric cancer. Furthermore, serum HGF levels should be studied
as a tumor marker in patients with gastric cancer.
|dc.title||Role of Serum Hepatocyte Growth Factor in Gastric Cancer Patients||-|
|dc.title.alternative||위암 환자에서 혈청 간세포 성장인자의 역할||-|
|dc.subject.keyword||Hepatocyte growth factor||-|
|dc.citation.title||Taehan Oekwa Hakhoe||-|
|dc.identifier.bibliographicCitation||Taehan Oekwa Hakhoe, 56(5):691-700, 1999||-|
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