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Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinomas

Other Title
간세포암에서 혈관내피성장인자 발현의 의의
Authors
홍, 성우; 왕, 희정; 김, 욱환; 소, 의영; 김, 명욱; 진, 윤미
Citation
Taehan Oekwa Hakhoe, 57(1):81-85, 1999
Journal Title
Taehan Oekwa Hakhoe; 대한외과학회지
ISSN
1226-0053
Abstract
Background : A tumor must continuously stimulate the growth of new capillary blood

vessels for the tumor itself to grow and metastasize. Vascular endothelial growth factor

(VEGF) promotes vascular permeability and endothelial cell growth. A hepatocellular

carcinoma (HCC) is a typical hypervascular tumor.

Methods : We evaluated the expression of VEGF in 36 cases of HCC by using

immunohistochemical staining in order to define its prognostic value.

Results : The expression rate of VEGF was 44.4% (16/36) in tumor cells and 0%

(0/36) in non-tumorous liver parenchyme. VEGF expression did not correlate with any

clinicopathological characteristics. And patients with expression of VEGF in tumor cells

had no survival difference in comparison to those without VEGF expression.

Conclusions : These results suggest that the expression of VEGF in HCC cells by

itself may not be a significant factor in the prognosis of HCC.
Keywords
Vascular endothelial growth factorHepatocellular carcinoma
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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