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Role of Vascular Endothelial Growth Factor in the Progression and Prognosis of Gastric Carcinomas

Other Title
위암의 진행 및 예후에 미치는 혈관내피성장인자의 역할
Authors
한, 상욱; 류, 기선; 소, 의영; 주, 희재; 조, 용관; 김, 명욱
Citation
Taehan Oekwa Hakhoe, 57(2):224-231, 1999
Journal Title
Taehan Oekwa Hakhoe; 대한외과학회지
ISSN
1226-0053
Abstract
Background : Solid tumors require neovasculization for growth and metastasis.

Recently, several angiogenic factors have been identified. Vascular endothelial growth

factor (VEGF) is thought to be one such angiogenic factor and is also thought to be a

selective mitogen for endothelial cells. In this study, we examined the expression of

VEGF and its relationship with microvessel density, and we also determined its

prognostic significance in gastric cancer patients.

Methods : One hundred one specimens resected from patients with gastric carcinomas

were investigated by staining with a polyclonal antibody against VEGF. Correlations

between the expression of VEGF, the microvessel density, various clinicopathologic

factors, and the patient's survival were studied.

Results : The normal gastric mucosa was not immunoreactive with an anti-VEGF

antibody. VEGF was mainly localized to the cytoplasm or the membrane of the

carcinoma cell. Of the 101 tumors, strong VEGF expression was detected in 48 (47.5%)

tumors. VEGF expression was correlated with depth of tumor invasion, lymph-node

metastasis, and stage. Microvessel density, determined by immunohistochemical staining

for CD3l, was significantly higher in VEGF-strong tumors than in VEGF-weak tumors.

Also, patients wish VEGF-strong tumors had a significantly poorer prognosis than those

with VEGF-weak tumors. However, multivariate analysis indicated that the expression

of VEGF was not an independent prognostic factor in patients with gastric cancer.

Conclusions : The fact that VEGF expression in gastric carcinomas was more

prevalent in more advanced tumors means that VEGF may contribute to the progression

of the tumor. Further study is needed to evaluate the significance of VEGF as a

prognostic factor.
Keywords
Vacular endothelial growth factorMetastasisPrognosisGastric carcinoma
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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
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