129 266

Cited 20 times in

Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer.

Authors
Jeong, NH; Song, ES; Lee, JM; Lee, KB; Kim, MK; Cheon, JE; Lee, JK; Son, SK; Lee, JP; Kim, JH; Hur, SY; Kwon, YI
Citation
Acta obstetricia et gynecologica Scandinavica, 88(4):457-462, 2009
Journal Title
Acta obstetricia et gynecologica Scandinavica
ISSN
0001-63491600-0412
Abstract
OBJECTIVE: We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. DESIGN: Hospital-based case-control study. SETTING: Six tertiary medical institutes in Korea. POPULATION: Forty-five epithelial ovarian cancers and 135 age-matched controls. METHODS: Preoperative plasma concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. MAIN OUTCOME MEASURES: Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. RESULTS: Women in the highest tertile for beta-carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), alpha-tocopherol (OR 0.23; 95%CI 0.10-0.53) and gamma-tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. CONCLUSIONS: Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, alpha-tocopherol, and gamma-tocopherol, may play a role in reducing the risk of ovarian cancer.
MeSH terms
AdultAnalysis of VarianceAntioxidants/metabolismCarotenoids/blood*Case-Control StudiesChromatography, High Pressure LiquidConfidence IntervalsFemaleHumansKorea/epidemiologyMiddle AgedNeoplasms, Glandular and Epithelial/blood*Neoplasms, Glandular and Epithelial/epidemiologyOdds RatioOvarian Neoplasms/blood*Ovarian Neoplasms/epidemiologyRisk FactorsTocopherols/blood*Vitamin A/blood*
DOI
10.1080/00016340902807215
PMID
19266359
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
AJOU Authors
이정필
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse