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Demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors in the gastroesophageal reflux disease group.

Authors
Lee, KJ; Kwon, HC; Cheong, JY; Cho, SW
Citation
Digestion, 79(3):131-136, 2009
Journal Title
Digestion
ISSN
0012-28231421-9867
Abstract
BACKGROUND/AIMS: The diagnostic criteria for nonerosive reflux disease (NERD) and functional heartburn (FH) have been changed. We investigated demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors (PPIs) in the gastroesophageal reflux disease (GERD) group. METHODS: Ninety-five patients with heartburn underwent endoscopy, 24-hour esophageal pH-metry and then a PPI test. NERD was diagnosed when % time with pH <4 was >4%, a symptom index (SI) >or=50% or a positive PPI test in patients without erosive esophagitis. Patients without such findings were classified as FH. RESULTS: Thirty-six patients had erosive reflux disease (ERD), 36 had NERD, and 23 had FH. The proportion of males was significantly higher in ERD than in FH. Atypical symptoms and IBS were more prevalent in FH than in ERD. Anxiety was more prevalent in FH than in NERD. The prevalence of pathologic acid reflux, a positive SI and a positive PPI test was similar between ERD and NERD patients. In the ERD and NERD groups, depression was independently associated with nonresponsiveness to PPIs. CONCLUSIONS: FH is a different entity from ERD or NERD, particularly in terms of gender, acid reflux patterns, psychological profiles, and the responsiveness to PPIs.
MeSH terms
Enzyme Inhibitors/therapeutic useEsophageal pH MonitoringFemaleGastroesophageal Reflux/drug therapy*Gastroesophageal Reflux/pathologyHeartburn/classification*Heartburn/drug therapyHeartburn/epidemiology*Heartburn/pathologyHumansMaleMiddle AgedPrevalenceTreatment Outcome
DOI
10.1159/000209848
PMID
19307735
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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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