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TRAPc as a Marker of Antioxidant System in Korean Type 2 Diabetic Patients

DC Field Value Language
dc.contributor.author이, 관우-
dc.contributor.author하, 애화-
dc.contributor.author김, 현만-
dc.date.accessioned2011-12-29T02:29:34Z-
dc.date.available2011-12-29T02:29:34Z-
dc.date.issued1999-
dc.identifier.issn1015-6380-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/5089-
dc.description.abstractBackground: It has been suggested that diabetic patients are under high oxidative

stress and plasma MDA concentration is a reliable marker for oxidative stress. However, some studies showed that plasma MDA is not a good marker for oxidative stress.

Recently, the total radical-trapping antioxidant parameter (TRAPc) has been proposed as a marker for the overall antioxidant property of plasma samples. Therefore, in this study, we tried to evaluate whether MDA and TRAPc are reliable markers of the oxidative stress-antioxidant system or not.

Methods: The plasma samples from 67 type 2 diabetic patients and 31 normal subjects

were collected. The plasma MDA, protein-bound SH groups, uric acid and vitamin C

were determined by fluorophotometry or spectrophotometry. Plasma vitamin I

concentration was analyzed by HPLC. Calculated TRAP (TRAPc) were determined by

the proposed calculation methods.

Results : 1. Diabetic patients had significantly lower TRAPc, compared with normal subjects.

2. SH groups, uric acid, vitamin C and vi拉min I were not different between the two

groups.

3. MDA and MDA/TG were significantly higher in diabetic subjects.

Conclusion : From the results of this study, TRAPc seems to be a reliable parameter

of overall plasma antioxidant system and the plasma MDA may be used as a marker of

oxidative stress, but further long-term logitudinal studies are needed.
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dc.language.isoko-
dc.titleTRAPc as a Marker of Antioxidant System in Korean Type 2 Diabetic Patients-
dc.title.alternative제2형 당뇨병 환자의 혈장 총항산화 방어체계의 지표로서TRAPc(Total radical trapping antioxidant parameter, calculated)-
dc.typeArticle-
dc.identifier.urlhttp://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0356619990140010134-
dc.subject.keywordDiabetes-
dc.subject.keywordOxidative-
dc.subject.keywordStress-
dc.subject.keywordVitamins-
dc.type.localJournal Papers-
dc.citation.titleJournal of Korean Society of Endocrinology-
dc.citation.title대한내분비학회지-
dc.citation.volume14-
dc.citation.number1-
dc.citation.date1999-
dc.citation.startPage134-
dc.citation.endPage141-
dc.identifier.bibliographicCitationJournal of Korean Society of Endocrinology, 14(1):134-141, 1999-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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