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Plasma ghrelin levels and their relationship with gastric emptying in patients with dysmotility-like functional dyspepsia.

Authors
Lee, KJ; Cha, DY; Cheon, SJ; Yeo, M; Cho, SW
Citation
Digestion, 80(1):58-63, 2009
Journal Title
Digestion
ISSN
0012-28231421-9867
Abstract
BACKGROUND/AIMS: Ghrelin affects gastric motility. However, little is known about the role of ghrelin in the pathophysiology of functional dyspepsia (FD). We investigated plasma ghrelin levels and their relationship with gastric emptying time in dysmotility-like FD patients. METHODS: 42 patients with dysmotility-like FD and 14 healthy volunteers were enrolled in the study. Gastric half-emptying time was measured using a radiolabeled meal. Plasma total ghrelin levels before and after the meal were determined using a radioimmunoassay kit. RESULTS: Preprandial ghrelin levels were significantly lower in FD patients than in controls. Postprandial ghrelin levels were similar between the two groups. Abnormally low preprandial ghrelin levels were observed in 7 out of 42 patients, in whom significant postprandial decrease of ghrelin levels was absent. Delayed gastric emptying was observed in 5 out of 7 patients with abnormally low ghrelin levels. Pre- or postprandial ghrelin levels were not significantly correlated with gastric half-emptying time, both in the patient group and in the control group. CONCLUSIONS: Abnormally low preprandial ghrelin levels and absence of significant postprandial decrease of ghrelin levels are present in a subset of dysmotility-like FD patients. Further investigation on the pathogenetic implication of these alterations in FD is required.
MeSH terms
AdultAgedCase-Control StudiesDyspepsia/blood*Dyspepsia/physiopathologyFemaleGastric Emptying*Ghrelin/blood*Ghrelin/deficiencyHumansMaleMiddle AgedPostprandial PeriodYoung Adult
DOI
10.1159/000215389
PMID
19494492
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > Research Organization > Genomic Research Center for Gastroenterology
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이광재여말희조성원
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