Experimental Cholesteatoma by Transplanting a Free Skin Graft in the Bulla of Mongolian Gerbil
증이강내 자가피부이식으로 유도한 심험적 진주종
박, 기현; 전, 영명; 김, 성민; 이, 동훈
Taehan Ibi Inhukwa Hakhoe chi, 39(7):1138-1143, 1996
Taehan Ibi Inhukwa Hakhoe chi; Journal of the Korean Otolaryngological Society; 대한이비인후과학회지
Despite its innocent histopathologic apprearance, cholesteatoma may follow an aggresive clinical course with extensive bone destruction leading to deafness, vertigo and meningeal and brain involvement. The assessment of the pathogenesis of the
cholesteatomas in human subject is limited because they are generally not recognized until symptoms occur, that is, at a later stage of the disease. There have been several studies using experimental animal models to clarify the characteristics
cholesteatoma. In the present study, an autologous free skin graft taken from the auricle was transplanted in the otic bulla of 16 normal adult mongolian gerbils In 8 of them, the graft was placed directly over the intact mucosa(group 1). In
was placed on the exposed bone following removal of the mucous membrane(group 2). After completion of these procedures, mongolian gerbils were sacrificed three months later for histological study.
1) After three months, epidermal cyst simulating cholesteatoma vas produced in 58% over all. In group 1, it was produced with 50%. And in group 2 it was produced with 64.3%.
2) Accumulation of keratin debris inside the cyst and subepithelial inflammatory cells were noted. No histological difference between group 1 and proup 2 could be seen, but group 2 seemed to have more subepithelial inflammatory cells.
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