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Increased Proliferating Activity and Bcl-2 Protein Expression in Eutopic Endometrium with Endometriosis

Other Title
자궁내막증 자궁내막에서의 세포 증식도와 Bcl-2 단백질 발현의 증가
김, 미란; 이, 재훈; 서, 성석; 장, 혜진; 황, 경주; 김, 영아; 박, 동욱
Taehan Sanbuinkwa Hakhoe chi, 48(8):1942-1949, 2005
Journal Title
Taehan Sanbuinkwa Hakhoe chi; Korean journal of obstetrics and gynecology; 대한산부인과학회지
Objective: To evaluate the expression of proliferating activity and Bcl-2 protein property in eutopic endometrium with endometriosis.

Methods: Endometrial tissues were obtained for endometrial biopsy from 2 groups of women. The study groups were 10 samples, which consisted of eutopic endometrial tissue with endometriosis. The remaining 10 samples were control group, which consisted of eutopic endometrial tissue without endometriosis. Expressions of Ki-67 and Bcl-2 protein were immunohistochemically investigated by polyclonal antibody. The computer program (Image pro (+), USA) was used to analysis the staining intensity of tissue samples objectively. Endometrial cells were cultured for 72 hours and the MTT colorimetric assay was used to detect cell proliferation.

Results: In the group of eutopic endometrium with endometriosis, the activity of cell proliferation was significantly increased. The expression of Ki-67 protein and MTT assay were significantly higher than those in the control group. And expression of Bcl-2 protein was significantly higher than those in the control group (P<0.05).

Conclusion: Eutopic endometrium with endometriois showed increasing Bcl-2 protein expression and increasing proliferation. It was believed to be associated with endometrial pathological abnormalities in endometriosis.
EndometriosisEndometriumProliferationBcl-2 protein
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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