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F-18-FDG Imaging Using Dual-Head Coincidence Positron Emission Tomography in Patients with Head and Neck Cancer

Other Title
두경부암에서 감마카메라를 이용한 FDG영상의 임상적 유용성
고, 중화; 정, 연훈; 양, 해동; 전, 정민; 박, 찬희; 배, 문선
Taehan Ibi Inhukwa Hakhoe chi, 43(6):649-654, 2000
Journal Title
Taehan Ibi Inhukwa Hakhoe chi; Journal of the Korean Otolaryngological Society; 대한이비인후과학회지
Background and Objectives : An accurate, Preoperative assessment of tumor extent and lymph node

involvement is necessary to plan and tailor therapy for patients with head and neck cancer. Metabolic

imaging with fluorine-18-fluorodeoxyglucose (FDG) is a good method to detect primary cancers in the

head and neck and to assess the involvement of lymph nodes, But it is not widely available because of

high cost of positron emission tomography (PET). Recently, an alternative method for using FDG was

developed : the coincidence detection PET (CoDe PET) using a gamma camera. The aim of this study

was to evaluate the clinical utility of FDG CoDe PET using a gamma camera in patients with head and

neck cancer. Materials and Methods : Thirty FDG CoDe PET studies were performed in 7 patients before

therapy and 19 patients after therapy with various head and neck cancers (Age : 25 - 79 years, mean age

: 50±13 years, 18 men, 8 women). All patients had fasted for 6 to 12 hours and were injected 111 to 370

MBq of F-18-FDG 1 hour before imaging. With the exception of the physilolgical FDG uptake, all

visually detectable focal FDG uptake in the primary cancer site or in the neck was considered positive.

FDG CoDe PET studies were correlated with CT/MRI. The standard procedure for detecting the presence

of disease was the combinations of repeated MRIs, 3 months of follow-up clinical evaluation and the

result of a needle aspiration cytology or biopsy. Results : FDG CoDe PET had a detection rate that was

comparable to that of CT/MRI in the pre-therapy group. However, in the post-therapy group, FDG CoDe

PET could differentiate residual/recurrence of tumor from radiation change more accurately then could

MRI. But, it had a less accurate detection rate for cervical metastases because of asymmetric neck muscle

uptake. Conclusion : FDG CoDe PET is a sensitive and cost-effective method to detect primary tumor

and lymph node involvement in primary head and neck cancers. It is also useful in differentiating residual

tumor or tumor recurrence from post-therapy changes in patients with head and neck cancers.
Coincidence PETHead and neck cancerF-18-FDG
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Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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