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Management of Osteoradionecrosis of the Mandible in Patients with Oral and Oropharyngeal Cancers

DC Field Value Language
dc.contributor.author정, 연훈-
dc.contributor.author이, 한국-
dc.contributor.author강, 성석-
dc.contributor.author최, 은창-
dc.contributor.author김, 귀언-
dc.contributor.author변, 성규-
dc.contributor.author차, 인호-
dc.date.accessioned2012-01-18T02:33:42Z-
dc.date.available2012-01-18T02:33:42Z-
dc.date.issued2000-
dc.identifier.issn1225-035X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/5292-
dc.description.abstractBACKGROUND AND OBJECTIVES: Osteoradionecrosis (ORN) of the mandible is one of the most serious complications following radiotherapy for oral and oropharyngeal cancer. However, the predisposing factors and clinical course of ORN are variable and its proper management is currently undetermined. The objective of this study is to review our ORN cases and evaluate the treatment methods.
PATIENTS AND METHODS: We retrospectively reviewed 57 cases of oral and oropharyngeal cancers, where patients received combined surgery and radiotherapy from 1990 to 1998. Osteoradionecrosis occurred in 5 cases, and we evaluated the predisposing factors, clinical course and results of treatments. Four patients were treated with radical sequestrectomy and open reduction of mandible. Of these four patients, three received the combined treatment with hyperbaric oxygen (HBO) therapy, and one received the conservative treatment.
RESULTS: Four ORN cases occurred at the lateral mandibulotomy site and one case arose at the opposite mandibular body unrelated to osteotomy. The interval between ORN and radiotherapy was so variable as 3 to 140 months. Four patients were successfully treated with the combined surgical and HBO therapies (3 cases) or with the conservative treatment (1 case). The remaining case could not be controlled by surgical treatment without HBO.
CONCLUSION: Osteoradionecrosis usually occurred at lateral mandibulotomy sites, especially combined with sagittal partial mandibulectomies. We recommend that lateral mandibulotomies should, whenever possible, be avoided if the radiotherapy is planned postoperatively. And the patients who received radiotherapy at the mandible should be observed for osteoradionecrosis for long time. Our treatment results suggest that a combined surgery with HBO therapy can be a primary treatment modality for ORN.
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dc.formatapplication/pdf-
dc.language.isoko-
dc.titleManagement of Osteoradionecrosis of the Mandible in Patients with Oral and Oropharyngeal Cancers-
dc.title.alternative구강 및 구인두암 환자의 하악골에 발새한 방사선골괴사의 치료-
dc.typeArticle-
dc.subject.keyword하악골-
dc.subject.keyword방사선골괴사-
dc.subject.keyword구강암-
dc.subject.keyword구인두암-
dc.subject.keyword고압산소치료-
dc.subject.keywordOsteoradionecrosis-
dc.subject.keywordOral and oropharyngeal cancer-
dc.subject.keywordHyperbaric oxygen therapy-
dc.subject.keywordMandible-
dc.contributor.affiliatedAuthor정, 연훈-
dc.type.localJournal Papers-
dc.citation.titleJournal of the Korean Otolaryngological Society-
dc.citation.volume43-
dc.citation.number10-
dc.citation.date2000-
dc.citation.startPage1109-
dc.citation.endPage1115-
dc.identifier.bibliographicCitationJournal of the Korean Otolaryngological Society, 43(10). : 1109-1115, 2000-
dc.relation.journalidJ01225035X-
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Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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