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Estradiol Supplement Therapy during Controlled Ovarian Hyperstimulation in Patients of IVF-ET with Thin Endometrium

Other Title
체외수정시술 및 배아 이식술의 시행시 자궁내막이 얇은 환자에서 과배란 유도시 에스트라디올 추가 요법의 효용성
한, 기수; 권, 혁찬; 황, 경주; 이, 치형; 양, 정인; 김, 미란; 오, 기석
Taehan Sanbuinkwa Hakhoe chapchi, 42(7):1457-1464, 1999
Journal Title
Taehan Sanbuinkwa Hakhoe chapchi; Korean journal of obstetrics and gynecology; 대한산부인과학회잡지
Objective: To evaluate the endometrial response and the receptivity of estradiol supplement in patients with abnormally thin endometrium who were undergoing IVF-ET. Methods : Design: A prospective, nonrandomized study. Setting: Ajou University School of Medicine, Suwon, Korea. Patients: A total of 772 IVF-ET cycles divided into four groups by endometrial thickness on the day of hCG injection and applied protocols. Interventions: Estradiol supplement before/during COH using GnRH agonist long protocol in patients with less than 7mm endometrial thickness from the previous cycle on the day of hCG administration. Main Outcome Measures: Incidence of patients with improved endometrial thickness 7mm, quality of transferred embryos and pregnancy rate were compared. Result[s]: Patients with thin endometrium [<7mm] in their previous cycle had a 74.1% [20/27] chance in cycles with estradiol supplement before/during COH to develop optimal endometria more than 7mm comparable to a 78.3% [18/23] chance in subsequent cycles of long term estrogen replacement. The pregnancy rate was markedly improved after the treatment protocol[9.5% vs. 30.7%]. Conclusion[s]: In cases where the endometrium is not adequate in the previous cycle, it is suggested that estradiol supplement before/during COH using GnRH agonist long protocol is effective.
Thin endometriumEstradiol supplement
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Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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