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Natural History of Chronic Hepatitis Type B throughout Long-term Follow-up

DC Field Value Language
dc.contributor.author이, 광재-
dc.contributor.author한, 광엽-
dc.contributor.author전, 재윤-
dc.contributor.author문, 영명-
dc.contributor.author이, 상인-
dc.contributor.author박, 인서-
dc.contributor.author김, 호근-
dc.contributor.author박, 찬희-
dc.contributor.author오, 희철-
dc.date.accessioned2012-02-03T04:52:35Z-
dc.date.available2012-02-03T04:52:35Z-
dc.date.issued1997-
dc.identifier.issn1598-9992-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/5501-
dc.description.abstractBackground/Aims: Chronic hepatitis type B is highly-prevalent in Korea. However, few studies about its natural history and prognostic factors have been presented until now. The natural course and long-term prognosis of chronic hepatitis type B varies greatly, and this diversity makes it difficu]t to predict the clinical course of individual patients. The histologic finding is known to be a important prognostic factor. Thus we conducted this study to evaluate the natural history and prognostic factors of chronic hepatitis type B in Korea.



Methods: The authors analyzed the clinical courses of 147 patients with clinicopathologically proven chronic hepatitis type B through long-term follow-up from the time of the initial biopsy according to histologic classification. 15 patients had chronic persistent hepatitis(CPH). 61 patients had chronic active hepatitis without bridging necrosis(CAH-BN). 46 patients had chronic hepatitis with bridgung necrosis(CAH+BN). 25 patients had chronic active hepatitis with early cirrhotic change(CAH+LC). They were followed for 24 to 150 months(mean 70.8(+25.8)).



Results: The probability of developing cirrhosis in chronic hepatitis type B was 0%, 2%, 10%, 18%, 23%, 28%, 37%, 49%, 54% in 1 year to 9 years, respectively. The 5-year cumulative probability of developing cirrhosis was 9% in CPH, 14% in CAH-BN, 22% in CAH+BN, and 55% in CAH+LC. The significant prognostic factors of developing cirrhosis were age(p<0.01) and histologic classification(p<0.001). The probability of developing decompensated cirrhosis in chronic hepatitis type B was 0%, 0%, 0%, 1%, 5%, 13%, 17%, 28%, and 32% in 1 year to 9 years, respectively. The probability of developing hepatocellular carcinoma(HCC) in chronic hepatitis type B was 0%, 0%, 0%, 1%, 3%, 3%, 6%, 8% and 8% in 1 year to 9 years, respectively. The significant prognostic factor of developing HCC was age.



Conclusions: The results of this study explored the natural history and prognostic factors of chronic hepatitis type B. 5-year cumulative probability of developing cirrhosis, decompensated cirrhosis and HCC was 23%, 5% and 3%, respectively. Histologic classification and age were significant prognostic factors for the development of cirrhosis. Age was a significant prognostic factor for the development of HCC. (Korean J Gastroenterol 1997;29:343 - 351)
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dc.language.isoko-
dc.titleNatural History of Chronic Hepatitis Type B throughout Long-term Follow-up-
dc.title.alternative장기간의 추적관찰에 따른 만성 B형 간염의 자연경과-
dc.typeArticle-
dc.subject.keywordChronic hepatitis type B-
dc.subject.keywordLiver cirrhosis-
dc.subject.keywordHepatocellular carcinoma-
dc.type.localJournal Papers-
dc.citation.titleThe Korean journal of gastroenterology-
dc.citation.titleTaehan Sohwagi Hakhoe chi-
dc.citation.volume29-
dc.citation.number3-
dc.citation.date1997-
dc.citation.startPage343-
dc.citation.endPage351-
dc.identifier.bibliographicCitationThe Korean journal of gastroenterology, 29(3):343-351, 1997-
dc.identifier.eissn2233-6869-
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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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