Impact of the Ratio of Graft Kidney Volume to Recipient Body Surface Area on Estimated Glomerular Filtration Rate
Lee, Jong Hoon; Won, Je Hwan; Oh, Chang-Kwon
Department of Surgery
The graft kidney volume and its weight have been reported as the surrogates of the amount of nephron mass. Ninety-five cases of live kidney donor were measured the bilateral kidney volumes including graft kidney volume using the computed tomography scanning with 3-deimensional reconstruction before transplantation, and also graft weight during operation. The impact of the ratio of the surrogates to recipient body surface area(BSA) on the graft function within 6 months post-transplantation were investigated. The graft kidney volume/recipient BSA ratio was inversely correlated with the serum creatinine (SCr) of recipients at 1 month and 6 months post-transplantation (r=-0.498, p<0.001 and r=-0.468, p<0.001, respectively). The graft kidney volume/recipient BSA ratio was different between the groups of recipients with SCr≤1.4mg/dL and recipients with SCr≥1.5mg/dL (p<0.001). The multivariable analysis demonstrated independent predictors of recipient SCr at 1 month and 6 months post-transplantation to be graft kidney volume/recipient BSA ratio and donor age (p<0.05). During living donor and recipient matching, both the potential volume of the donated kidney and body size of recipient should be considered.
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