Methicillin-Resistant-Staphylococcus aureus Theraphy for the Treatment of Methicillin-Resistant-Staphylococcus aureus Infected Wounds

Abstract

Purpose:Methicillin-Resistant-Staphylococcus aureus (MRSA) has been increasingly recognized as a cause of nosocomial infection. MRSA is hardly-controllable organism among the pathogen of nosocomial infection, because it is resistant to most antibiotics except vancomycin, and local treatment with most antiseptics are not effective to eradicate MRSA from the infection. The effectiveness of Vacuum-Assisted-Closure(VAC) was reported widely. we tried to modify original VAC. We tried VAC dressing on MRSA infected wound to evaluate whether or not the VAC is effective to eradicate MRSA which existed in the open wound. Methods:From September 2003 to December 2003, 24 patients admitted to the plastic and reconstructive surgery and orthopedic surgery, were studied. All patients were found to be positive in previous wound. Using clinical randomized study, 24 patients were divided into two groups: VAC dressing group and the Betadine(R) dressing group(control). During treatment, wound culture was done twice a week for evaluation of MRSA infection elimination. Results:The mean period that MRSA become not detected in all case was 17.1 days in VAC dressing group, and 25.8 days in control group, respectively. The p value was 0.013. The result reveals that the VAC dressing group is more effective to MRSA infection control. As a result, the VAC dressing was more effective in MRSA infected wound than conventional dressing. Conclusions:Through this study, we found objective result of VAC dressing. We hope that VAC dressing is more widely applied to fresh and infected wound.