Clinical Analysis of Eight Cases of Mucormycosis

Abstract

Background and objectives：Invasive fungal sinusitis can present as either an indolent or fulminant process that primarily affects immunocompromised individuals. Rhinocerebral mucormycosis with intracranial involvement has a high mortality. Materials and Method：Clinical characteristics of eight cases of mucormycosis in patients were analyzed retrospectively and previous reports in the literature were reviewed. Results：We treated the patients with correction of underlying disease, wide local excision, debridement of all involved and devitalized oral, nasal, sinus, and orbital tissue and intravenous amphotericin B. Three patients survived and five patients died. Conclusion：Mainstays of treatment include antifungal agents and radical resection of necrotic tissue. Reversal of the underlying medical condition, when possible, is a critical part of the management. The favorable outcome was attributable to early diagnosis and management of focal areas of mucormycosis.