A case of bronchial asthma due to cefadroxil in a housewife
가정주부에서 발생한 cefadroxil에 의한 기관지천식 1례
최, 정희; 서, 유진; 정, 재욱; 송, 현주; 서, 창희; 남, 동호; 박, 해심
Chʿŏnsik mit alrerugi, 22(4):736-741, 2002
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
Cephalosporins are the most important β-lactams that induce IgE-mediated reactions. Also, cephalosporins have been known as a causative agent for occupational asthma in pharmaceutical workers. To our knowledge, this is the first report of
cephalosporin-induced bronchial asthma in a housewife with no history of occupational exposure.
We experienced a 30-year old female who had developed shortness of breath, coughing and itching sensation of the skin since 3 years ago whenever she handled drug powder for upper respiratory infections (URI) prescribed for her two sons with
asthma. She had handled drug powder for 7 years because her sons had experienced frequent URI. Skin prick test with cefadroxil (10 ㎎/㎖) and cefaclor (10 ㎎/㎖) showed positive reactions. Bronchial challenge test with cefadroxil showed immediate
asthmatic reaction, and bronchial challenge with cefaclor showed immediate urticaria and angioedema without significant fall in FEV1. We confirmed cefadroxil-induced bronchial asthma sensitized by intermittent inhalation in a non-occupational
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