0 128

Cited 0 times in

Clinical significance of serum ECP and sero-prevalence of human toxocariasis in patients with eosinophilia

Other Title
호산구증가증 환자에서 혈청 ECP의 임상적 의의 및 개회충증의 혈청 양성률
Authors
최, 정희; 서, 유진; 정, 재욱; 송, 현주; 허, 선; 서, 창희; 남, 동호; 박, 해심
Citation
Chʿŏnsik mit alrerugi, 23(1):26-32, 2003
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
ISSN
1226-8739
Abstract
BACKGROUND: Several studies have reported that the serum concentration of eosinophil cationic protein (ECP) reflects the intensity of eosinophilic airway inflammation in asthmatic patients, and the ratio of serum ECP concentration to peripheral blood

eosinophil counts (ECP/Eo ratio) may be useful in assessing asthma severity. Human toxocariasis, of which diagnosis relies upon specific serology, is a common. worldwide helminthozoonosis and one of the causes of blood eosinophilia. OBJECTIVES: The aim

of this study is to evaluate the clinical significance of serum ECP concentration, peripheral-blood eosinophil count and ECP/Eo ratio in relation to clinical severity, and the sero-prevalence of human toxocariasis in patients with eosinophilia.

MATERIALS AND METHODS: Fifteen patients with eosinophilia were enrolled. Serum ECP concentrations by CAP system, peripheral-blood eosinophil counts, and ECP/Eo ratio were determined. Clinical severity of the disease was represented as the number of

organs with eosinophilic infiltration, and we divided the study subjects in to two groups according to therapeutic response. The diagnosis of toxocariasis was confirmed by detecting serum specific IgE antibody to Toxocara excretory-secretory antigens

(TES-Ag) by ELISA and IgG immunoblot analysis. RESULTS: A significant positive correlation was found between the number of organs with eosinophilic infiltration, serum ECP concentration, and peak peripheral-blood eosinophil count (p < 0.05,

respectively). The number of organs with eosinophilic infiltration was significantly higher in the poor therapeutic response group compared to the good therapeutic response group (p < 0.01). Fourteen of 15 patients (93.3%) showed positive reactions in

Toxocara serologic test. CONCLUSION: Toxocara infection should be considered as a major cause of eosinophilia in this country. Serum ECP, peak peripheral-blood eosinophil count and the number of organs with eosinophilic infiltration may be used as

useful markers for assessment of therapeutic response in patients with eosinophilia.
Keywords
eosinophiliaeosinophil cationic proteintoxocariasis
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse