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Development of water-insoluble chitosan patch scaffold to repair traumatic tympanic membrane perforations.
DC Field | Value | Language |
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dc.contributor.author | Kim, JH | - |
dc.contributor.author | Bae, JH | - |
dc.contributor.author | Lim, KT | - |
dc.contributor.author | Choung, PH | - |
dc.contributor.author | Park, JS | - |
dc.contributor.author | Choi, SJ | - |
dc.contributor.author | Im, AL | - |
dc.contributor.author | Lee, ET | - |
dc.contributor.author | Choung, YH | - |
dc.contributor.author | Chung, JH | - |
dc.date.accessioned | 2010-12-14T04:46:01Z | - |
dc.date.available | 2010-12-14T04:46:01Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/564 | - |
dc.description.abstract | Perforated tympanic membranes (TM) and otitis media can be managed with a paper patch or tympanoplasty. However, a paper patch is not biocompatible and tympanoplasty requires complex aseptic surgical procedures. A novel biocompatible patch with a water-insoluble chitosan as the main component was prepared. Optimal mechanical characteristics of a water-insoluble chitosan patch scaffold (CPS) was approximately 40 microm in thickness, 7 MPa in tensile strength, and 107% in percent elongation, even though the characteristics varied significantly depending on the concentrations of chitosan and glycerol. SEM of the CPSs showed a very smooth surface as compared with that of the paper patches. These CPSs showed no cytotoxicity and had a stimulating effect on the proliferation of TM cells in in vitro study. In in vivo study, 4 (21.1%) and 17 (89.5%) TMs out of 19 adult rats with CPSs showed no perforations at 1 and 2 weeks, respectively. However, left control TMs showed healing of 0 (0%) at 1 week and 18 (94.7%) at 2 weeks. TEM findings of regenerated eardrums using CPSs showed thinner, smoother, and more compact tissues than spontaneously healed eardrums. A CPS was more effective than spontaneous healing to repair traumatic TM perforations. | - |
dc.language.iso | en | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biocompatible Materials | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Chitosan | - |
dc.subject.MESH | Materials Testing | - |
dc.subject.MESH | Microscopy, Electron, Scanning | - |
dc.subject.MESH | Microscopy, Electron, Transmission | - |
dc.subject.MESH | Otitis Media | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Stress, Mechanical | - |
dc.subject.MESH | Tensile Strength | - |
dc.subject.MESH | Tympanic Membrane | - |
dc.subject.MESH | Tympanic Membrane Perforation | - |
dc.subject.MESH | Water | - |
dc.subject.MESH | Wound Healing | - |
dc.title | Development of water-insoluble chitosan patch scaffold to repair traumatic tympanic membrane perforations. | - |
dc.type | Article | - |
dc.identifier.pmid | 18546188 | - |
dc.contributor.affiliatedAuthor | 정, 연훈 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1002/jbm.a.32119 | - |
dc.citation.title | Journal of biomedical materials research. Part A | - |
dc.citation.volume | 90 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 446 | - |
dc.citation.endPage | 455 | - |
dc.identifier.bibliographicCitation | Journal of biomedical materials research. Part A, 90(2). : 446-455, 2009 | - |
dc.identifier.eissn | 1552-4965 | - |
dc.relation.journalid | J015493296 | - |
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