Tissue engineering and regenerative medicine, 6(14):1327-1342, 2009
Tissue engineering and regenerative medicine
In the design of perfusion bioreactor system for tissue engineering, design parameters including fluid dynamics and mass transport as well as scaffolds should be optimized to maximize cell growth. Critical elements in bioreactor systems based on cells and scaffolds include sell seeding, the nutrient and gas supply to cells, and mechanical stimuli. In particular, perfusion flow systems have been shown to enhance cell growth, differentiation, and tissue formation as well as provide for the appropriate and necessary mass transfer of nutrients, gases, metabolites, and regulatory molecules. In this paper, we reviewed the biomechanical models in relation with fluid dynamics, mass transport, and shear stress with scaffolds. Therefore, obtaining a proper oxygen supply, high cell density, and an uniform cell distribution in a three-dimensional growth support are important. Both experiments and quantitative mathematical models of cell culture in perfusion bioreactors are needed to better understand physical, mechanical, and biochemical conditions and for the design of a suitable bioreactor system the mathematical describes the oxygen mass transfer and cell density within a three-dimensional scaffold. This review focuses on bionechanical models in relation with fluid dynamics, mass transport, and shear stress to cells cultured, and cell growth in pergusion bioreactors for tissue engineering.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :2,032,149
Total Download :862,520
Today View :612
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.