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Changes of serum neutrophil chemotactic activity(NCA) and myeloperoxidase (MPO) level following lysine-aspirin(L-ASA) bronchoprovocation test in aspirin-sensitive asthmatic patients

Other Title
아스피린 과민성 천식 환자에서 아스피린 기관지유발시험 전후의 혈청 호중구 화학주성능과 myeloperoxidase치의 변화
Authors
김, 선신; 김, 희연; 남, 동호; 강, 경령; 정, 기석; 박, 해심
Citation
Chʿŏnsik mit alrerugi, 19(2):181-187, 1999
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
ISSN
1226-8739
Abstract
Background : There have been few reports suggesting involvement of mast cell and

neutrophil to induce bronchoconstriction in aspirin-sensitive asthma.

Objective : To evaluate mast cell and neutrophil activation in pathogenesis of

aspirin-sensitive asthma.

Material and methods : We observed changes of serum NCA and MPO levels during

L-ASA bronchoprovocation test in 14 subjects with aspirin-sensitive asthma.

Results : Serum NCA was significantly increased at 30 min(p=0.01) after the

inhalation of L-ASA and then, no significant changes were noted at 240 min(p=0.14).

NCA was significantly higher in subjects with late asthmatic responses than in those

without it(p=0.04). Serum MPO level tended to increase at, 30 min with no statistical

significance(p=0.08), and then it significantly decreased at 240 min (p=0.05). There was

no significant correlation between serum NCA and MPO level(r=0.22, p=0.58).

Conclusion : These results support the view that NCA derived from mast cell may

contribute to neutrophil recruitment into the airway in aspirin-sensitive asthmatic

patients.
Keywords
serum neutrophil chemotactic activitymast cellaspirin-sensitive asthma
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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