A case of intravenous immunoglobulin therapy in severe aspirin-sensitive asthma patient combined with IgG1 and IgG3 subclass deficiency

Abstract

Common complications in a patient with IgG subclass deficiency include recurrent respiratory infections and concomitant inflammatory lung disease. The most effective therapy in these patients is the administration of intravenous immunoglobulin. The authors report a case of severe aspirin-sensitive asthma and recurrent pneumonia with combined IgG1 and IgG3 subclass deficiency in a 19-year-old man. The patient was treated with 0.4g/㎏ at monthly intervals for 6 months, and is still receiving 0.2g/㎏ every 2 weeks at our clinic. After the replacement of in travenous immunoglobulin, the patient has clinically improved.