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Clinical significance of specific IgG and IgE antibodies to toluene diisocyanate (TDI)-human-serum albumin (HSA) conjugate in TDI-induced occupational asthma

Other Title
Toluene diisocyanate(TDI)에 의한 직업성천식에서 TDI-인혈청 알부민 접합체에 대한 특이 IgG 및 IgE 항체의 임상적 의의
김, 희연; 서, 정희; 남, 동호; 박, 해심; 손, 지웅; 김, 유영
Chʿŏnsik mit alrerugi, 19(4):594-600, 1999
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
Background and Objective : TDI is known to be the most prevalent cause of

occupational asthma (OA) in Korea. However, the pathogenesis of TDI-induced

occupational asthma still remains to be further clarified. So, we evaluated clinical

significance of serum specific IgG and IgE antibodies to TDI-HSA conjugate in

TDI-induced occupational asthma.

Subjects and Methods : Serum specific IgG and IgE antibodies to TDI-HSA conjugate

were measured by enzyme linked immunosorbent assay. Serum was collected from 50

TDI- induced OA patients (classified as group Ⅰ), and was compared with that from 13

asthmatic subjects with negative TDI-bronchoprovocation test (BPT, group Ⅱ), allergic

asthmatics (group Ⅲ), and unexposed healthy controls (group Ⅳ).

Results : The prevalence of specific IgG was significantly higher in group Ⅰ than in

group Ⅱ (p=0.01) or group Ⅲ (p<0.01). No significant difference was noted between

group Ⅱ and group Ⅲ (p>0.05). However, the prevalence of specific IgE was not

different between group Ⅰ and group Ⅱ (p>0.05) or group Ⅱ and group Ⅲ (p>0.05).

There was no significant difference in prevalence of specific IgG according to the

asthmatic response during TDI bronchoprovocation test (p>0.05). No statistical

significance was noted between specific IgG and IgE antibodies in group Ⅰ subjects


Conclusion : These findings demonstrate that presence of specific IgG to TDI-HSA

conjugate is closely related to TDI-BPT results and it may contribute to the

development of TDI-induced asthma.
TDI-induced occupational asthmaspecific IgGspecific IgETDI-bronchoprovocation test
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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