Prevalence of autoantibodies in sera from atopic and non-atopic asthmatics
아토피성 및 비아토피성 기관지천식 환자의 혈청내 항핵항체 및 항갑상선 자가항체의 양성률 비교
남, 동호; 김, 선신; 이, 수걸; 박, 해심
Chʿŏnsik mit alrerugi, 20(2):229-235, 2000
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
Background and objectives：There have been several reports showing increased prevalences of various autoantibodies in non-atopic asthma compared to atopic asthma. And the possible involvement of autoimmune mechanisms in the pathogenesis of
asthma has been suggested. To evaluate this hypothesis, we compared the prevalence of circulating autoantibodies in sera from patients with non-atopic and atopic asthma.
Subjects and methods：Serum samples from 23 patients with non-atopic asthma showing no visible skin reaction to 50 common inhalant allergens and serum total IgE levels below 200 IU/ml, 23 patients with atopic asthma who showing positive skin
and positive allergen bronchoprovocation tests, 34 age-matched healthy volunteers, and 20 patients with systemic lupus erythematosus were enrolled. We screened IgG antinuclear antibody by indirect immunofluorescence test using HEp-2 cell, and IgG
autoantibodies to thyroglobulin and thyroid peroxidase by radioimmunoassay.
Results：IgG antinuclear antibodies were found in 1 (3%) of 34 healthy volunteers, 3 (13%) of 23 patients with non-atopic asthma, none of 23 patients with atopic asthma, 19 (95%) of 20 patients with systemic lupus erythematosus. IgG
thyroglobulin or thyroid peroxidase were found in 2 (6%) of 34 healthy volunteers, 2 (9%) of 23 patients with non-atopic asthma, 1 (4%) of 23 patients with atopic asthma, and 4 (25%) of 20 patients with systemic lupus erythematosus.
Conclusion：There was no evidence for increased prevalence of autoantibodies to nuclear and thyroid antigen in sera from atopic and non-atopic asthmatics compared to healthy controls.
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