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Prevalence of autoantibodies in sera from atopic and non-atopic asthmatics

Other Title
아토피성 및 비아토피성 기관지천식 환자의 혈청내 항핵항체 및 항갑상선 자가항체의 양성률 비교
Authors
남, 동호; 김, 선신; 이, 수걸; 박, 해심
Citation
Chʿŏnsik mit alrerugi, 20(2):229-235, 2000
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
ISSN
1226-8739
Abstract
Background and objectives:There have been several reports showing increased prevalences of various autoantibodies in non-atopic asthma compared to atopic asthma. And the possible involvement of autoimmune mechanisms in the pathogenesis of

non-atopic

asthma has been suggested. To evaluate this hypothesis, we compared the prevalence of circulating autoantibodies in sera from patients with non-atopic and atopic asthma.

Subjects and methods:Serum samples from 23 patients with non-atopic asthma showing no visible skin reaction to 50 common inhalant allergens and serum total IgE levels below 200 IU/ml, 23 patients with atopic asthma who showing positive skin

prick

tests

and positive allergen bronchoprovocation tests, 34 age-matched healthy volunteers, and 20 patients with systemic lupus erythematosus were enrolled. We screened IgG antinuclear antibody by indirect immunofluorescence test using HEp-2 cell, and IgG

autoantibodies to thyroglobulin and thyroid peroxidase by radioimmunoassay.

Results:IgG antinuclear antibodies were found in 1 (3%) of 34 healthy volunteers, 3 (13%) of 23 patients with non-atopic asthma, none of 23 patients with atopic asthma, 19 (95%) of 20 patients with systemic lupus erythematosus. IgG

autoantibodies

to

thyroglobulin or thyroid peroxidase were found in 2 (6%) of 34 healthy volunteers, 2 (9%) of 23 patients with non-atopic asthma, 1 (4%) of 23 patients with atopic asthma, and 4 (25%) of 20 patients with systemic lupus erythematosus.

Conclusion:There was no evidence for increased prevalence of autoantibodies to nuclear and thyroid antigen in sera from atopic and non-atopic asthmatics compared to healthy controls.
Keywords
Bronchial asthmaAutoantibodiesAtopyNon-atopy
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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