A case of acetaminophen induced bronchial asthma -without aspirin sensitivity-
아스피린 과민성을 동반하지 않은 아세트아미노펜 과민성 천식 1례
김, 선신; 이, 수걸; 남, 동호; 박, 해심
Chʿŏnsik mit alrerugi, 20(3):545-550, 2000
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
Acetaminophen is a widely used analgesic-antipyretic. Hypersensitivity reactions to acetami-
nophen are rare and selective sensitivity to acetaminophen without aspirin or non-steroidal antiinflammatory drug intolerance is even rarer. We experienced a case of acetaminophen- induced bronchial asthma without aspirin sensitivity. An oral
test upto 650mg of Tylenol demonstrated urticaria and dyspnea with greater than 20% decrease of FEV1. Both oral provocation test with 500mg of aspirin and lysine-aspirin bronchoprovocation test showed negative results. In conclusion, we report a
of acetaminophen-induced asthma without aspirin sensitivity. Cyclo-oxygenase inhibition may not be a pathogenic mechanism of acetaminophen-induced bronchial asthma. Further studies will be needed to clarify the mechanism of this reaction.
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