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A case of acetaminophen induced bronchial asthma -without aspirin sensitivity-

Other Title
아스피린 과민성을 동반하지 않은 아세트아미노펜 과민성 천식 1례
김, 선신  | 이, 수걸 | 남, 동호  | 박, 해심
Journal of asthma, allergy and clinical immunology, 20(3). : 545-550, 2000
Journal Title
Journal of asthma, allergy and clinical immunology
Acetaminophen is a widely used analgesic-antipyretic. Hypersensitivity reactions to acetami-nophen are rare and selective sensitivity to acetaminophen without aspirin or non-steroidal antiinflammatory drug intolerance is even rarer. We experienced a case of acetaminophen- induced bronchial asthma without aspirin sensitivity. An oral challenge test upto 650mg of Tylenol demonstrated urticaria and dyspnea with greater than 20% decrease of FEV1. Both oral provocation test with 500mg of aspirin and lysine-aspirin bronchoprovocation test showed negative results. In conclusion, we report a case of acetaminophen-induced asthma without aspirin sensitivity. Cyclo-oxygenase inhibition may not be a pathogenic mechanism of acetaminophen-induced bronchial asthma. Further studies will be needed to clarify the mechanism of this reaction.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Ajou Authors
김, 선신  |  남, 동호  |  박, 해심
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