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Localization of transforming growth factor β1 in airway mucosa of toluene diisocyanate-induced asthma

DC Field Value Language
dc.contributor.author이, 수걸-
dc.contributor.author이, 선민-
dc.contributor.author함, 기백-
dc.contributor.author임, 현이-
dc.contributor.author박, 충식-
dc.contributor.author김, 선신-
dc.contributor.author남, 동호-
dc.contributor.author박, 해심-
dc.date.accessioned2012-02-16T05:08:33Z-
dc.date.available2012-02-16T05:08:33Z-
dc.date.issued2001-
dc.identifier.issn1226-8739-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/5714-
dc.description.abstractBackground and objective: There have been some reports on the expression of TGF β-an anti-inflammatory and fibrosing cytokine in airway mucosa of asthmatics. However, the ex- pression of TGF β1 in bronchial mucosa of TDI-induced asthma is not

known.

The aim of this study was to observe immunolocalization of TGF β1 in airway mucosa of TDI-induced asthma.

Methods: TGF β1 expressions were compared using immunohistochemistry in bronchial muco- sa from 22 subjects with TDI-induced asthma (group I: 10 newly diagnosed, group II: 12 subjects with persistent asthma symptoms for more than 4 years after

diagnosis), and 8 non- asthmatics undergoing pneumonectomy from lung tumor. The distribution and intensity of expression were analyzed by two observers in four areas of bronchial tissue-epithelium(EP), vascular endothelium(VE), smooth muscle(SM),

and

mucous glands(MG).

Results: Positive rates of TGF β1 expression for groups Ⅰ and Ⅱ in the four areas were as follows; EP (50% vs 100%, p<0.05), VE(40% vs 100%, p<0.05), SM(33.3% vs 100%, p<0.05), and MG(66.7% vs 80%, p>0.05). Grades of TGF β1 expression of EP,

VE, and

SM were significantly higher in group II than in group I(p<0.05, respectively). There was no significant difference in distribution and intensity of TGF β1 expression between TDI-induced asthma and controls(p>0.05, respectively).

Conclusion: TGF β1 expressions of EP, VE, SM and MG were noted in airway mucosa of TDI-induced asthma and expressions of EP, VE, and SM were more intense and frequent in patients with persistent asthma symptoms.
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dc.language.isoko-
dc.titleLocalization of transforming growth factor β1 in airway mucosa of toluene diisocyanate-induced asthma-
dc.title.alternativeToluene diisocyanate에 의한 천식 환자의 기도 점막내 transforming growth factor β1의 발현 양상-
dc.typeArticle-
dc.subject.keywordLocalization of TGF β1-
dc.subject.keywordbronchial mucosa-
dc.subject.keywordTDI-induced asthma-
dc.type.localJournal Papers-
dc.citation.titleChʿŏnsik mit alrerugi-
dc.citation.titleJournal of asthma, allergy and clinical immunology-
dc.citation.titleKorean journal of asthma, allergy and clinical immunology-
dc.citation.title천식 및 알레르기-
dc.citation.volume21-
dc.citation.number3-
dc.citation.date2001-
dc.citation.startPage500-
dc.citation.endPage507-
dc.identifier.bibliographicCitationChʿŏnsik mit alrerugi, 21(3):500-507, 2001-
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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