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Localization of transforming growth factor β1 in airway mucosa of toluene diisocyanate-induced asthma

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dc.contributor.author이, 수걸-
dc.contributor.author이, 선민-
dc.contributor.author함, 기백-
dc.contributor.author임, 현이-
dc.contributor.author박, 충식-
dc.contributor.author김, 선신-
dc.contributor.author남, 동호-
dc.contributor.author박, 해심-
dc.description.abstractBackground and objective: There have been some reports on the expression of TGF β-an anti-inflammatory and fibrosing cytokine in airway mucosa of asthmatics. However, the ex- pression of TGF β1 in bronchial mucosa of TDI-induced asthma is not


The aim of this study was to observe immunolocalization of TGF β1 in airway mucosa of TDI-induced asthma.

Methods: TGF β1 expressions were compared using immunohistochemistry in bronchial muco- sa from 22 subjects with TDI-induced asthma (group I: 10 newly diagnosed, group II: 12 subjects with persistent asthma symptoms for more than 4 years after

diagnosis), and 8 non- asthmatics undergoing pneumonectomy from lung tumor. The distribution and intensity of expression were analyzed by two observers in four areas of bronchial tissue-epithelium(EP), vascular endothelium(VE), smooth muscle(SM),


mucous glands(MG).

Results: Positive rates of TGF β1 expression for groups Ⅰ and Ⅱ in the four areas were as follows; EP (50% vs 100%, p<0.05), VE(40% vs 100%, p<0.05), SM(33.3% vs 100%, p<0.05), and MG(66.7% vs 80%, p>0.05). Grades of TGF β1 expression of EP,

VE, and

SM were significantly higher in group II than in group I(p<0.05, respectively). There was no significant difference in distribution and intensity of TGF β1 expression between TDI-induced asthma and controls(p>0.05, respectively).

Conclusion: TGF β1 expressions of EP, VE, SM and MG were noted in airway mucosa of TDI-induced asthma and expressions of EP, VE, and SM were more intense and frequent in patients with persistent asthma symptoms.
dc.titleLocalization of transforming growth factor β1 in airway mucosa of toluene diisocyanate-induced asthma-
dc.title.alternativeToluene diisocyanate에 의한 천식 환자의 기도 점막내 transforming growth factor β1의 발현 양상-
dc.subject.keywordLocalization of TGF β1-
dc.subject.keywordbronchial mucosa-
dc.subject.keywordTDI-induced asthma-
dc.type.localJournal Papers-
dc.citation.titleChʿŏnsik mit alrerugi-
dc.citation.titleJournal of asthma, allergy and clinical immunology-
dc.citation.titleKorean journal of asthma, allergy and clinical immunology-
dc.citation.title천식 및 알레르기-
dc.identifier.bibliographicCitationChʿŏnsik mit alrerugi, 21(3):500-507, 2001-
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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