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Sputum induction method for studying total IgE levels in atopic asthmatic patients

Other Title
기관지천식 환자의 기관지분비물내 총 IgE 항체치 연구에서 유도객담검사의 유용성
Authors
김, 상돈; 서, 창희; 김, 희연; 남, 동호; 박, 해심
Citation
Chʿŏnsik mit alrerugi, 18(2):299-307, 1998
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
ISSN
1226-8739
Abstract
Background : IgE antibodies have been considered to play an important role in the

pathogenesis of atopic asthma. However, there have been only few studies on the role

of IgE in airway secretion in the pathogenesis of bronchial asthma. This might be partly

due to difficulty in sampling of airway secretion from asthmatic patients. Recently,

sputum induction method by inhalation of nebulized hypertonic saline was developed, and

proved to be valid and useful method for obtaining airway secretion from asthmatic

patients for studying airway inflammation.

Objective and method : To evaluate the usefulness of sputum induction method for

studying IgE antibodies in airway secretion from atopic asthmatic patients, total IgE

levels in induced sputum from 54 atopic asthmatics were measured by enzyme-linked

immunosorbent assay(ELISA) and tried to find an association with sputum eosinophilia..

Result : Total IgE levels in induced sputum were significantly higher in atopic

asthmatic patients(1,27 ±82.066 IU/㎖) than in controls(0.203±0.291 IU/㎖)(p<0.05). In

atopic asthmatic patients, total IgE levels in induced sputum were not significantly

different between patients with and without sputum eosinophilia(≥5% of 200 counted

leukocytes). There was a significant correlation of total IgE levels between induced

sputum and serum in atopic asthmatic patients(r=0.60, p<0.05). Total IgE levels in

induced sputum(1.278±2.066) were significantly higher than sativa sample(0..504±1.111

lu/㎖) from atopic asthmatic patients (p<0.05).

Conclusion : These results suggest that total IgE levels are increased in the induced

sputum of atopic asthmatic patients and sputum induction method is a useful tool for

studying IgE antibodies in airway secretion from asthmatic patients.
Keywords
bronchial asthmaIgE antibodyinduced sputumenzyme-linked immunosorbent assayeosinophil
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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