Local production of specific IgE antibody to house dust mite in nasal polyp tissues

Abstract

Objective : In order to confirm the local production of total and specific IgE antibodies in the nasal polyp tissues. Material and method: We measured total IgE and house dust mite(Dermatophagoides pteronpssinus : DP)-specific IgE antibody using enzyme-linked immunosorbent assay(ELISA) in the supernatant of nasal polyp homogenates from 72 subjects undergoing nasal polypectomy. The subjects were divided into three groups according to skin reactivity to DP: 20 strongly atopic subjects to group I(mean wheal diameter) 3mm), 19 weakly atopic subjects to group II (mean wheal diameter 1-3mm) and 33 negative skin responders to group III. Result: Group I showed significantly higher levels of total and DP-specific IgE levels in the nasal polyp ...