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Prevalence of sensitivity to aspirin (ASA) and food additives in subjects diagnosed as having intrinsic asthma

Other Title
기관지천식 환자에서 아스피린과 음식첨가물에 대한 과민성의 빈도
박, 해심; 조, 요한; 김, 선신; 김, 희연; 남, 동호; 서, 창희; 한, 명호
Chʿŏnsik mit alrerugi, 18(4):662-671, 1998
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
Objective and method : In order to identify the aggravating agents for intrinsic

asthma, we performed ASA- and food additive-challenge tests on 182 subjects

diagnosed as haying intrinsic asthma. The following tests were performed :

Lysine-aspirin bronchoprovocation test to confirm aspirin-sensitivity, sodium bi-sulfite

(40∼200mg) oral provocation test for sulfite sonsitivity, tartrazine oral provocation test

(50mg) for tartrazine sensitivity, and sodium benzoate (400mg) oral provocation test for

sodium benzoate sensitivity. Positive reaction was defined as decrease in

FEV1 by more than 20% from the baseline value after the provocation.

Result : Seventy-five (41.2%) of 182 subjects showed positive responses to more than

one agent among the aspirin and three food additives challenged. The prevalence of

aspirin-sensitivity was the highest (22.5%), followed by sulfite-sensitivity (8.8%), and

then concurrent sensitivity to both aspirin and sulfite (6.0%), to both aspirin and

tartrazine (1.6%), to aspirin, sulfite and tartrazine (1.1%) and to aspirin, sulfite and

sodium benzoate (0.5%). Rhino-sinusitis was noted in 62.5% of aspirin-sensitive

asthmatic subjects, 60% of sulfite-sensitive ones, and 80% of tartrazine-sensitive ones.

Urticaria was noted in 21.4% of aspirin-sensitive asthmatic subjects, 16.6% of

sulfite-sensitive ones and 6.3% of tartrazine-sensitive ones. Thirty-seven to 83% of

positive responders had no adverse reaction history.

Conclusion : These findings suggest that ASA and food additive challenge tests

should be considered as a screening test to evaluate any aggravating factors in subjects

with intrinsic asthma, even though they may not have experienced any adverse

ASAfood additiveprovocation testintrinsic asthma
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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