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Serum Specific IgE to Staphylococcal Superantigens in Sera of ASA-intolerant Asthma

Other Title
아스피린 불내성 천식환자에서 포도상구균에 대한 혈청 특이 IgE 항체 측정
Authors
오, 정미 | 김, 승현 | 윤, 성호 | 김, 상하 | 서, 창희  | 남, 동호  | 박, 해심
Citation
Korean journal of asthma, allergy and clinical immunology, 24(2). : 247-252, 2004
Journal Title
Korean journal of asthma, allergy and clinical immunology
ISSN
1226-8739
Abstract
Objective : Several studies suggest that serum total IgE (tIgE) level tended to be higher in ASA-intolerant asthma (AIA) than in other types of non-atopic asthma, whether they are atopics or non-atopics. A pathogenic role of superantigens was suggested in inflammatory responses of upper respiratory allergy with increased IgE production. To investigate a role of staphylococcal superantigens in AIA, we measured serum specific IgE level to three staphylococcal superantigens (SEA, SEB, TSST-1) in the sera of ASA-tolerant asthma (AIA), ASA tolerant asthma (ATA) patients, and normal control (NC).
METHOD : Fifty-six AIA patients showing positive responses on L-ASA bronchoprovocation test, 40 ATA, and 30 non-atopic healty controls were enrolled. Serum specific IgE to three staphylococcal superantigens were measured by CAP system (Pharmacia, Uppsala, Sweden).
RESULT : The prevalences of specific IgE to each superantigens were highest in AIA, followed by ATA and NC. Significanct differences were noted in the prevalence of IgE to TSST-1 and SEB between AIA and NC (P<0.05, respectively). Serum total IgE levels were significantly higher in superantigen-positive AIA patients (P<0.05, respectively). Furthermore, in non-atopic AIA patients, those with TSST-1 specific IgE had significantly higher total IgE levels (P<0.05, respectively). There were no correlations between superantigen-specific IgE level and sex, atopy status or presence of urticaria. Significant correlations were found between specific IgE to SEB or TSST-1 and serum total IgE level (r=0.42, 0.30, P<0.05), and specific IgE to TSST-1 and PC20 methacholine (r=-0.36, P<0.05). No significant correlations were found between superantigen-specific IgE and serum soluble CD30 level or cumulative dose of L-ASA inhaled.
CONCLUSION: Superantigen may contribute to increase in serum total IgE level, in particular, significant association with TSST-1 was noted in non-atopic AIA patients. Further studies will be needed to investigate how they contribute to AIA pathophysiology.
Keywords

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Ajou Authors
남, 동호  |  박, 해심  |  서, 창희
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