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Methacholine-induced Bronchial Hyperresponsiveness in Patients with Main Stem Endobronchial Tumor

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dc.contributor.author양, 두경-
dc.contributor.author이, 수걸-
dc.contributor.author손, 춘희-
dc.contributor.author노, 미숙-
dc.contributor.author최, 필조-
dc.contributor.author이, 진화-
dc.contributor.author김, 기남-
dc.contributor.author이, 기남-
dc.contributor.author이, 영목-
dc.contributor.author박, 해심-
dc.contributor.author남, 동호-
dc.date.accessioned2012-02-22T05:27:04Z-
dc.date.available2012-02-22T05:27:04Z-
dc.date.issued2005-
dc.identifier.issn1226-8739-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/5781-
dc.description.abstractBackground: Patients with main stem endobronchial tumor may have wheeze on physical examination, which mimics bronchial asthma.
Objective: We evaluated the role of methacholine induced bronchial hyperresponsiveness, which is a hallmark of bronchial asthma, in differentiating these patients from patients with bronchial asthma.
Methods: The provocative concentrations of methacholine required to reduce FEV1 by 20% of the pre-challenge baseline (PC20) and the prevalence of hyperresponsiveness were compared among patients with main stem endobronchial tumor (n=8), patients with symptomatic bronchial asthma (n=15) and normal healthy controls (n=10).
Results: PC20 in patients with main stem endobronchial tumor (17.2+/-3.9 mg/mL) and normal healthy controls (23.9+/-3.2 mg/mL) were significantly higher than those in patients with bronchial asthma (6.3+/-2.3 mg/mL). Prevalence of hyperresponsiveness (PC20<25.0 mg/mL of methacholine) was higher in patients with bronchial asthma than that in patients with endobronchial tumor, or normal healthy controls (86.7% vs. 37.5%, 86.7% vs. 10.0%, P<.05 respectively). There were no significant correlations between clinical parameters (FVC, FEV1, peripheral blood eosinophil count, total IgE level) and PC20 in patients with main stem endobronchial tumor.
Conclusion: It is reasonable to consider the possibility of endobronchial tumor in patients who have wheeze on physical examination, but do not have methacholine-induced bronchial hyperresponsiveness.
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dc.formatapplication/pdf-
dc.language.isoko-
dc.titleMethacholine-induced Bronchial Hyperresponsiveness in Patients with Main Stem Endobronchial Tumor-
dc.title.alternative주기관지 종양 환자에서 메타콜린 기도과민성 조사-
dc.typeArticle-
dc.identifier.urlhttps://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001150088-
dc.subject.keywordHyperresponsiveness-
dc.subject.keywordAsthma-
dc.subject.keywordNeoplasm-
dc.contributor.affiliatedAuthor박, 해심-
dc.contributor.affiliatedAuthor남, 동호-
dc.type.localJournal Papers-
dc.citation.titleKorean journal of asthma, allergy and clinical immunology-
dc.citation.volume25-
dc.citation.number2-
dc.citation.date2005-
dc.citation.startPage104-
dc.citation.endPage109-
dc.identifier.bibliographicCitationKorean journal of asthma, allergy and clinical immunology, 25(2). : 104-109, 2005-
dc.relation.journalidJ112268739-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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