Sensory Neural Hearing Loss after Concurrent Cisplatin and Radiation Therapy for Nasopharyngeal Carcinoma
비인강암 환자에서 Cisplatin과 방사선 병합치료시 발생하는 감각신경성 청력손실
오, 영택; 강, 승희; 전, 미선; 고, 중화; 최, 진혁
Korean journal of head & neck oncology, 14(1):15-19, 1998
Korean journal of head & neck oncology; 대한두경부종양학회지
Objectives : It is expected that the combined cisplatin and radiation therapy far
nasopharyngeal carcinoma produces more sensory neural hearing losses compared to
radiation therapy alone. The purpose of this study was to evaluate the incidence of
sensory neural hearing losses after concurrent cisplatin and radiation therapy for nasopharyngeal carcinoma.
Materials and Methods : From fun. 1994 to Mar 1997, 10 patients were available for
this study with the 1311owing eligibility criteria : 1) The patients received concurrent cisplatin and radiation therapy for nasopharyngeal carcinoma. 2) There was no pre-existing auditory disease except serous otitis media due to nasopharyngeal
carcinoma. 3) They had normal sensorineural hearing function on the pretreatment pure
tone audiogram. 4) Pure tone audiograms were performed at least one time artier
treatment betiveen 6months to 1 year follow-up without local recurrence.
Results : At 1 year 1311ow-up, 3 patients complained of decreased hearing capacity.
Sensorineural hearing losses were developed in 15 ears out of 20(75%) and were more
frequent and severe in high frequency area on pure tone audiogram.
Conclusion : The concurrent cisplatin and radiation therapy for nasopharyngeal
carcinoma may produce sensorineural hearing losses more frequently compared to
historical data of radiation therapy alone and close evaluations with regular audiograms are necessary even in patients symptoms without symptoms and signs of hearing impairment.
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