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Comparative Study of ImmunoCAP and ELISA for Detecting Allergen Specific IgE to Japanese Hop Pollen and Two Spotted Spider Mite

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dc.contributor.author김, 현아-
dc.contributor.author예, 영민-
dc.contributor.author허, 규영-
dc.contributor.author김, 승현-
dc.contributor.author서, 창희-
dc.contributor.author남, 동호-
dc.contributor.author박, 해심-
dc.date.accessioned2012-02-23T01:33:55Z-
dc.date.available2012-02-23T01:33:55Z-
dc.date.issued2006-
dc.identifier.issn1226-8739-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/5805-
dc.description.abstractBackground & Objectives: Japanese hop pollen (Hop J) and two spotted spider mite (TSM) are common allergens in this country. The aim of this study was to validate a new immunoCAP test for detecting allergen-specific IgE to Hop J and TSM compared to skin reactivity and ELISA results.



Methods: Ninty-five allergy patients showing more than 2+ response on skin prick test to Hop J, 131 allergy patients showing more than 2+ response on skin prick test to TSM and 60 non-atopic healthy controls were enrolled. Skin prick testing was performed using homemade Hop J pollen and TSM extracts. The specific IgE levels to both homemade allergens were measured by ELISA, which were compared to those of the immunoCAP system.



Results: The positive rates of serum specific IgE to Hop J were 57% by ELISA and 51% by Pharmacia immunoCAP system among 95 patients tested. The positive rates of serum specific IgE to TSM were 28% by ELISA and 50% by immunoCAP system among 131 patients tested. A significant correlation was found in specific IgE level between ELISA and the immunoCAP system (r=0.63 for Hop J and r=0.61 for TSM, P<0.05).



Conclusion: The new immunoCAP system for detecting serum specific IgE antibodies to Hop J pollen was comparable to the results of other in vivo and in vitro test and can be applied for the diagnosis of Hop J-allergic patients. New immunoCAP system to TSM was superior to the ELISA test, and can be used for screening TSM-sensitive patients.
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dc.language.isoko-
dc.titleComparative Study of ImmunoCAP and ELISA for Detecting Allergen Specific IgE to Japanese Hop Pollen and Two Spotted Spider Mite-
dc.title.alternative알레르기 환자에서 ImmunoCAP 시스템을 이용한 환삼덩굴 및 점박이응애황원에 대한 특이 IgE치 측정: 피부반응도 및 ELISA 결과와의 비교-
dc.typeArticle-
dc.subject.keywordJapanese Hop Pollen-
dc.subject.keywordTwo Spotted Spider Mite-
dc.subject.keywordImmunoCAP system-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor허, 규영-
dc.contributor.affiliatedAuthor김, 승현-
dc.contributor.affiliatedAuthor서, 창희-
dc.contributor.affiliatedAuthor남, 동호-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.citation.titleChʿŏnsik mit alrerugi-
dc.citation.titleJournal of asthma, allergy and clinical immunology-
dc.citation.titleKorean journal of asthma, allergy and clinical immunology-
dc.citation.title천식 및 알레르기-
dc.citation.volume26-
dc.citation.number2-
dc.citation.date2006-
dc.citation.startPage129-
dc.citation.endPage135-
dc.identifier.bibliographicCitationChʿŏnsik mit alrerugi, 26(2):129-135, 2006-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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