The Efficacy and Safety of Cyclosporin A(Cipol-N soft capsule) in Adult Nephrotic Syndrome : 16 Weeks, Open Label, Multicenter Study
신증후군환자에 대한 사이크로스포린의 유효성 및 안전성 평가를 위한 16주 공개 다기관 제 3상 임상시험
Lee, HY; Shin, SK; Noh, HJ; Kim, HS; Shin, GT; Kim, DH; Kim, YL; Cho, DK; Hong, SP; Lee, TW; Ihm, CG; Kim, MJ
Taehan Sinjang Hakhoe chi, 19(2):249-258, 2000
Taehan Sinjang Hakhoe chi; The Korean journal of nephrology; 대한신장학회지
A multicenter prospective study was done in four-university hospital to evaluate the
efficacy and safety of cyclosporin A(CyA, Cipol-N ) in 64 patients with adult nephrotic syndrome [mean age 34.8 years, male:famale 2.4:1, duration of desease
38.0±40.9months, 31 patients with MCD, 33 patients with Non-MCD(8 FSGS, 14 MGN,
7 MPGN, 2 lupus nephritis, 1 HBsAg associated GN)]. The prior steroid responses of these patients were 17 steroid dependent, 9 frequent relapser, 4 steroid resistant and 1 other in MCD patients, and 5 steroid dependent, 5 frequent relapser, 22 steroid resistant and 1 other in Non-MCD patients. After a 2-week steroid(prednisolon 10㎎/day or deflazacor 12㎎/day) run-in period, CyA 5㎎/㎏/day and prednisolone 10㎎/day(or
deflazacor 12㎎/day) were administered for up to 16 weeks. Of the 64 patients enrolled,
11 patients were dropped out prematurely due to adverse events or protocol violation. Of
the 53 patients who completed the study, 27 had MCD and 26 had Non-MCD.
High response(CR and PR) rate of 68%(36/53) were obtained with CyA treatment in all patients. Although the response late in MCD was significantly higher than that in
Non-MCD(89 vs. 46%, p<0.05) and response rates were significantly different according
to the previous steroid responses by univariate analysis, only previous steroid responses affected the response to CyA significantly by Logistic multiple regression analysis(p=0.03, RR 7.08); responses were 84%(27/32) in steroid dependent and frequent relapser patients, and 37%(7/19) in steroid resistant patients. 24-hr proteinuria significantly decreased after 2 weeks and serum albumin and cholesterol increased significantly after 4 weeks of treatment compared to baseline level. The serum creatinine level was not changed during the study. No serious and unexpected side event was observed.
In conclusion, cyclosporine therapy is a safe and effective mode of treatment in
patients with nephrotic syndrome, especially in those who need prolonged administration
of steroids with resulting in unavoidable steroid complications such as frequent relapser and steroid dependent type. The patients with steroid resistant type and
contraindications of steroid administration such as DM, aseptic bone necrosis etc. can
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