A Case of Rheumatoid Arthritis Associated with Renal Amyloidosis and Crescentic Glomerulonephritis
류마토이드 관절염과 연관된 이차성 신유전분증에서의 반월상 사구체 신염 1예
Choi, JH; Im, BK; Cho, HK; Choi, YG; Kim, HS; Shin, GT; Kim, DH; Han, JH
Taehan Sinjang Hakhoe chi, 20(6):1058-1063, 2001
Taehan Sinjang Hakhoe chi; The Korean journal of nephrology; 대한신장학회지
A case of renal amyloidosis with crescentic glomerulonephritis associated with rheumatoid arthritis is described. A 60-year-old female with 15 years' history of rheumatoid arthritis developed nephrotic syndrome followed by rapid deterioration of
renal function. Glomerular amyloid deposition and sclerotic change was present in kidney biopsy specimen and crescentic change was found in 85% of the glomerulus. Electron microscopic finding of glomerulus showed randomly oriented, rigid-appearing,
long non-branching fibrils. The patients was treated with intravenous high-dose methylprednisolone pulses combined with intravenous cyclophosphamide followed by oral corticosteroids. Three months after the above treatment, renal function gradually
improved, reaching serum creatinine level to 2.5 ㎎/㎗. But the nephrotic range proteinuria persisted.
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