25 292

Cited 30 times in

Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro.

Authors
Park, CH; Kang, JS; Yoon, EH; Shim, JW; Suh-Kim, H; Lee, SH
Citation
FEBS letters, 582(5):537-542, 2008
Journal Title
FEBS letters
ISSN
0014-57931873-3468
Abstract
Roles of Nurr1 and neurogenin 2 (Ngn2) have been shown in midbrain dopamine (DA) neuron development. We present here rat and mouse species-dependent differences of Nurr1 and Ngn2 actions in DA neuron differentiation. Nurr1 exogene expression caused an efficient generation of tyrosine hydroxylase (TH)-positive DA cells from rat neural precursor cells (NPCs). Nurr1-induced TH+ cell yields were low and highly variable depending on the origins of NPCs in mouse cultures. Coexpression of Ngn2 repressed Nurr1-induced generation of TH+ cells in rat cultures. In clear contrast, a robust enhancement in Nurr1-induced DA cell yields was observed in mouse NPCs by Ngn2. These findings imply that DA neurons may develop differently in the midbrains of these two species.
MeSH terms
AnimalsBasic Helix-Loop-Helix Transcription Factors/geneticsBasic Helix-Loop-Helix Transcription Factors/metabolism*Cell Differentiation*DNA-Binding Proteins/geneticsDNA-Binding Proteins/metabolism*Dopamine/metabolism*Gene Expression RegulationHumansMiceNerve Tissue Proteins/geneticsNerve Tissue Proteins/metabolism*Neurons/cytology*Neurons/metabolismNuclear Receptor Subfamily 4, Group A, Member 2RatsRats, Sprague-DawleySpecies SpecificityStem Cells/cytology*Stem Cells/metabolismTranscription Factors/geneticsTranscription Factors/metabolism*Tyrosine 3-Monooxygenase/metabolism
DOI
10.1016/j.febslet.2008.01.018
PMID
18242186
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
AJOU Authors
서해영
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse