Acute Hyperphosphatemia & Hypocalcemia Following the Administration of Phosphate-containing Laxatives in Patients with End Stage Renal Disease

Abstract

Oral or rectal sodium phosphate(NaP) preparation is commonly used for the colonic cleansing. Since the sole route of excretion of absorbed phosphate is renal, diminished renal function will limit the ability to excrete a sudden phosphate load. To date, about 20 adult cases of hyerphosphatemia associated with oral or rectal sodium phosphate solution have been reported, but not a single case in Korea to our knowledge. We report two cases of hyperphosphatemia and hypocalcemia after the administration of NaP(Colclean®) to reemphasizes the potential hazard of sodium phosphate bowel preparation in patients with compromised renal function.