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Rit contributes to neurite outgrowth triggered by the alpha subunit of Go.

Authors
Kim, SH; Kim, S; Ghil, SH
Citation
Neuroreport, 19(5):521-525, 2008
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
Heterotrimeric GTP-binding protein transduce signals initiated by a variety of hormones and neurotransmitters. Go, a member of the Go/Gi family, is the most abundant heterotrimeric GTP-binding protein in nervous tissues and has been implicated in neuronal differentiation. The mechanism by which Go modulates neuronal differentiation has not been, however, fully elucidated. Here, we identified small GTPase Rit as an interacting partner of the alpha-subunit of Go (Goalpha). The biochemical characterizations of Goalpha::Rit interaction revealed that Rit is a candidate downstream effector for Goalpha. Furthermore, dominant negative Rit inhibited Goalpha-induced neurite outgrowth and Erk phosphorylation in Neuro2a cells. These results suggest that Rit may be involved in the signaling pathway for Goalpha-mediated neuronal differentiation.
MeSH terms
AnimalsCell Differentiation/physiology*Cell LineExtracellular Signal-Regulated MAP Kinases/metabolismGTP-Binding Protein alpha Subunits/physiology*Green Fluorescent Proteins/metabolismHumansImmunoprecipitation/methodsMiceNeurites/drug effectsNeurites/physiology*PhosphorylationSignal TransductionTransfectionTwo-Hybrid System Techniquesras Proteins/physiology*
DOI
10.1097/WNR.0b013e3282f9e473
PMID
18388731
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
AJOU Authors
김소연
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