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Prevalence & Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Isolates in Korea

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dc.contributor.author홍, 성근-
dc.contributor.author김, 선주-
dc.contributor.author정, 성훈-
dc.contributor.author장, 철훈-
dc.contributor.author조, 성란-
dc.contributor.author안, 지영-
dc.contributor.author신, 종희-
dc.description.abstractBackground : Increase in extended-spectrum p-lactamase(ESBL)-producing Escherichia coli and Klebsiella pneumoniae have beeh reported in Korea. The aim of this study was to determine the na¬tionwide prevalence of ESBL-producing E. coli and K pneumoniae, and to investigate the types of ESBLs.

Methods : A total of 2,221 E. coli and 11,128 K pneumoniae consecutive isolates were yearly col¬lected from 12 hospitals in 1999 and 2000. ESBL production was performed by National Committee for Clinical Laboratory Standards methods and double synergy tests. The type of ESBL was deter¬mined by polymerase chain reaction (PCR), isoelectric focusing, and nucleotide sequence analysis.

Results: ESBL-producing E. coli and K pneumoniae isolates were detected from all 12 hospitals participated. The proportion of ESBL-producers was 9.1%(2.0-19.6%) of the E. coli and 29.2% (10.0-60.8%) of the K pneumoniae isolates. Among the 22 isolates sequenced, SHV-12 was found in six isolates, SHV-2a in three isolates, TEM-52 in five isolates, TEM-106 in three isolates, and each of TEM-15, TEM-20, TEM-43, and TEM-107 in one isolate. CTX-M-14 was also found in one isolate.

Conclusion: ESBL-producing E. coli and K pneumoniae are widespred to all levels of Korean hospitals. The most common types of ESBLs in Korea are SHV-12, SHV-2a, and TEM-52. In addition, we also identified new TEM-derived ESBLs. (Korean J Ciin Microbiol 2003;6(2):149-155)
dc.titlePrevalence & Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Isolates in Korea-
dc.title.alternative국내에서 분리된 Extended-Spectrum β-Lactamase 생성 Escherichia coli와 Klebsiella pneumoniae의 빈도 및 유형-
dc.subject.keywordExtended-spectrum β-lactamase (ESBL)-
dc.subject.keywordEscherichia coli-
dc.subject.keywordKlebsiella pneumoniae-
dc.type.localJournal Papers-
dc.citation.titleTaehan Imsang Misaengmul Hakhoe chi-
dc.citation.titleKorean journal of clinical microbiology-
dc.identifier.bibliographicCitationTaehan Imsang Misaengmul Hakhoe chi, 6(2):149-155, 2003-
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Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
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