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Antineutrophil Cytoplasmic Antibodies (ANCA) in Patients with Behcet's Disease

Other Title
베체트병 환자에서 항호중구 세포질 항체(antineutrophil cytoplasmic antibodyANCA)의 검출
Authors
방, 동식; 윤, 경한; 진, 상현; 이, 은소; 이, 성낙
Citation
Korean journal of dermatology, 36(4):652-656, 1998
Journal Title
Korean journal of dermatology; 대한피부과학회지
ISSN
0494-4739
Abstract
Background : Antineutrophil cytoplasmic antibodies(ANCA) are autoantibodies against

cytoplasmic constituents of neutrophils, and have been detected in patients with

idiopathic necrotizing glomerulonephritis, crescenteric glomerulonephritis, Wegener's

granulomatosis, and polyarteritis nodosa. The induction of ANCA may result in

neutrophil mediated vascular injury. In Behest's disease mucosal and cutaneous lesions are often characterized by small vessel vasculitis. So the endothelial cell damage probably mediated by polymorphonuclear leukocytes has been regarded as an important pathophysiological mechanism in the disease. However, the literature has not showed the presence of ANCA in the disease, and it has been generally accepted that ANCA cannot

be incriminated as a contributing factor to the abnormalities of neutrophils in Behcet's

disease.

Objective : We examined the presence of ANCA in sera of 7 patients with Behest's

disease.

Method : We examined clinical and laboratory findings of 61 patients with Behest's

disease, who also had cutaneous manifestations due to vascular disorders. ANCA were demonstrated in the sera of the patients by the indirect immunofluorescence method.

Result : We found ANCA in the sera of 7 patients with complete or incomplete types

of Behcet's disease.

Conclusion : We do not yet know the meanings of the ANCA that were detected in Behest's disease. Moreover, we cannot retort against previous reports showing that ANCA were meaningless in Behest's disease in the aspects of pathophysiology.

However, it is clear that ANCA can be detected in patients with Behcet's disease, so it is necessary to investigate more about ANCA in Behest's disease.
Keywords
ANCABehcet's disease
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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