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Beta-catenin interacts with MyoD and regulates its transcription activity.

Authors
Kim, CH; Neiswender, H; Baik, EJ; Xiong, WC; Mei, L
Citation
Molecular and cellular biology, 28(9):2941-2951, 2008
Journal Title
Molecular and cellular biology
ISSN
0270-73061098-5549
Abstract
Wnt regulation of muscle development is thought to be mediated by the beta-catenin-TCF/LEF-dependent canonical pathway. Here we demonstrate that beta-catenin, not TCF/LEF, is required for muscle differentiation. We showed that beta-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity. MyoD-mediated transactivation is inhibited in muscle cells when beta-catenin is deficient or the interaction between MyoD and beta-catenin is disrupted. These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway.
MeSH terms
AnimalsCell DifferentiationCell LineGene Expression Regulation, DevelopmentalMiceMuscle, Skeletal/cytologyMyoblasts/cytologyMyoblasts/metabolismMyogenic Regulatory Factors/geneticsMyogenic Regulatory Factors/physiology*Protein BindingSignal TransductionTCF Transcription Factors/metabolismTranscriptional ActivationWnt Proteins/physiologybeta Catenin/physiology*
DOI
10.1128/MCB.01682-07
PMID
18316399
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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