Effect of MCT (medium-chain triglyceride) and LCT (long-chain triglyceride) on Myocardial Ischemiaf Reperfusion Injury and Platelet Aggregation in Rat

Abstract

Intravenous lipid emulsion is used extensively as a major component of parenteral nutrition for patients in the surgical intensive care unit. Abnormal cardiovascular function related to lipid infusion has been reported although conflicting results exist. In the present study, we investigated the effects of intravenous emulsions of long-chain..triglyceride (LCT) and medium-chain triglyceride (MCT) on myocardial ischemia/ reperfusion injury and on platelet..aggregaiion in rat.. There was no difference between LCT and MCT considering the effects on * left ventricular developed pressure (LVDP) and coronary flow rate ´ (CFR) before and after ischemia/reperfusion in isolated rat heart. On the other hand, a difference was found between LCT and MCT with regard to their effects on heart rate (HR) and end diastolic pressure (EDP) after ischemia/ reperfusion. After ischemia/reperfusion, HR was significantly (P<0.05) reduced and EDP significantly (P<0.05) increased by LCT (18±2.0% and 42.8±8.9%, respectively), but not by MCT. Ex vivo platelet aggregation induced by collagen was reduced by LCT infusion, but not by MCT. These findings suggest that MCT may have slightly more favorable effect than LCT on the myocardial function after ischemia/reperfusion in rat.