Effects of Crude Ginseng Saponin on the Thromboxane Synthesis in Lipopolysaccharide-stimulated Macrophages
Ryu, JH; Lee, SH; Moon, CH; Han, YN; Han, BH
Journal of Applied Pharmacology, 3(4):301-303, 1995
Journal of Applied Pharmacology; 응용약물학회지
Crude ginseng saponin fraction reduced the production of thromboxane A, in the lipopolysaccharidestimulated macrophages. Several kinds of crude saponins showed varient potency that might be caused by the compositional difference of ginseng saponins. From the metabolic labeling experimental data, this reduction of thromboxane A2 formation, at least in part, resulted from the reduction of protein synthesis of inducible isozyme of cyclooxygenase(COX-2). This activity may be resulted from the fact that ginseng saponins have steroidal moiety in their structures.
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