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Effects of Crude Ginseng Saponin on the Thromboxane Synthesis in Lipopolysaccharide-stimulated Macrophages

Authors
Ryu, JH; Lee, SH; Moon, CH; Han, YN; Han, BH
Citation
Journal of Applied Pharmacology, 3(4):301-303, 1995
Journal Title
Journal of Applied Pharmacology; 응용약물학회지
ISSN
1225-6110
Abstract
Crude ginseng saponin fraction reduced the production of thromboxane A, in the lipopolysaccharide­stimulated macrophages. Several kinds of crude saponins showed varient potency that might be caused by the compositional difference of ginseng saponins. From the metabolic labeling experimental data, this reduction of thromboxane A2 formation, at least in part, resulted from the reduction of protein synthesis of inducible isozyme of cyclooxygenase(COX-2). This activity may be resulted from the fact that ginseng saponins have steroidal moiety in their structures.
Keywords
ginsengsaponinthromboxane Acyclooxygenase
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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