Cited 0 times in
A functional SNP of the interleukin-18 gene is associated with the presence of hepatocellular carcinoma in hepatitis B virus-infected patients.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Cheong, JY | - |
dc.contributor.author | Cho, SW | - |
dc.contributor.author | Lee, KM | - |
dc.contributor.author | Hwang, JC | - |
dc.contributor.author | Oh, B | - |
dc.contributor.author | Kimm, K | - |
dc.contributor.author | Lee, JA | - |
dc.contributor.author | Park, BL | - |
dc.contributor.author | Cheong, HS | - |
dc.contributor.author | Shin, HD | - |
dc.contributor.author | Kim, JH | - |
dc.date.accessioned | 2010-12-16T05:30:03Z | - |
dc.date.available | 2010-12-16T05:30:03Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/616 | - |
dc.description.abstract | BACKGROUND/AIM: The natural course of hepatitis B virus (HBV) infection is likely related to host immune factors. Interleukin-18 (IL-18) plays a significant role in immune defense. This study was undertaken to determine the association between the presence of hepatocellular carcinoma (HCC) and single-nucleotide polymorphisms (SNPs) in the IL-18 gene in HBV-infected patients.
METHODS: Between March 2002 and December 2004, 730 Korean subjects were enrolled in two different groups: (1) chronic carrier without HCC (n = 637) and (2) HCC (n = 93). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C in the study subjects. To evaluate the functional significance of SNPs in the IL-18 gene promoter region, we performed a reporter gene assay in HepG2 and Hep3B cells transfected with different alleles. RESULTS: The IL-18 -148C allele, +8925G allele, +13925C allele, and haplotype 3 (TCGC) were associated with the presence of HCC in codominant and dominant models. Furthermore, functional analyses using the reporter gene assay revealed that the -148C allele conferred significantly lower promoter activity. CONCLUSIONS: This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are associated with the presence of HCC and the 148G>C SNP is functionally important in determining disease outcome. | - |
dc.language.iso | en | - |
dc.title | A functional SNP of the interleukin-18 gene is associated with the presence of hepatocellular carcinoma in hepatitis B virus-infected patients. | - |
dc.type | Article | - |
dc.identifier.pmid | 19757044 | - |
dc.contributor.affiliatedAuthor | 정, 재연 | - |
dc.contributor.affiliatedAuthor | 조, 성원 | - |
dc.contributor.affiliatedAuthor | 이, 기명 | - |
dc.contributor.affiliatedAuthor | 황, 재철 | - |
dc.contributor.affiliatedAuthor | 김, 진홍 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s10620-009-0970-6 | - |
dc.citation.title | Digestive diseases and sciences | - |
dc.citation.volume | 54 | - |
dc.citation.number | 12 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 2722 | - |
dc.citation.endPage | 2728 | - |
dc.identifier.bibliographicCitation | Digestive diseases and sciences, 54(12). : 2722-2728, 2009 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.relation.journalid | J001632116 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.