Effect of Steroid on Brain Tumors and Surround Edemas : Observation with Regional Cerebral Blood Volume (rCBV) Maps of Perfusion MRI
스테로이드가 뇌종양과 주변 부종에 미치는 영향 : 관류 자기공명영상의 국소 뇌혈류량 지도에 의한 관찰
최, 주열; 선, 주성; 김, 선용; 김, 지형; 서, 정호; 조, 경기; 김, 장성
Taehan Pangsasŏn Ŭihakhoe chi, 42(1):15-21, 2000
Taehan Pangsasŏn Ŭihakhoe chi; The journal of the Korean Radiological Society; 대한방사선의학회지
Purpose : To observe the hemodynamic change in brain tumors and peritumoral edemas
after steroid treatment, and then investigate the clinical usefulness of perfusion MRI.
Materials and Methods : We acquired conventional and perfusion MR images in 15
patients with various in tracranial tumors (4 glioblastoma multiformes, 4 meningiomas, 3 metastatic tumors, 1 anaplastic ependymoma, 1 anaplastic astrocytoma, 1
hemangioblastoma, and 1 pilocytic astrocytoma). For perfusion MR imaging, a 1.5T unit employing the gradient-echo EPI technique was used, and further perfusion MR images were obtained 2-10 days after intravenous steroid therapy. After processing of the raw data, regional cerebral blood volume (rCBV) maps were reconstructed. The maps were visually evaluated by comparing relative perfusion in brain tumors and peritumoral edemas with that in contralateral white matter. Objective evaluations were performed by
comparing the perfusion ratios of brain tumors and peritumoral edemas.
Result : Visual evaluations of rCBV maps, showed that in most brain tumors (67%,
10/15), perfusion was high before steroid treatment and showed in (80%, 12/15),
decreased afterwards. Objective evaluation, showed that in all brain tumors, perfusion
decreased. Visual evaluation of perfusion change in peritumoral edemas revealed change
in only one case, but objective evaluation indicated that perfusion decreased significantly in all seven cases.
Conclusions : rCBV maps acquired by perfusion MR imaging can provide hemodynamic
information about brain tumors and peritumoral edemas. Such maps could prove helpful in the preoperative planning of brain tumor surgery and the monitoring of steroid effects during conservative treatment.
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