36 111

Cited 0 times in

Carbofuran Induces Cardiovascular Dysfunction in Rat

Other Title
횐쥐의 심혈관 기능에 대한 carbofuran의 독성작용
Authors
정, 이숙; 이, 수환; 백, 은주; 문, 창규; 문, 창현
Citation
Yakhakhoe chi, 45(6):739-745, 2001
Journal Title
Yakhakhoe chi; Journal of the Pharmaceutical Society of Korea; 약학회지
ISSN
0377-9556
Abstract
Of all pesticides, carbamates are known to be most common, since alternatives such as organophosphates have long lifetime and are extremely toxic to produce a delayed neurotoxic effect. Although a number of studies about toxicity of carbofuran, a most widely used carbamate, have been reported, its cardiovascular toxicity has not yet been studied. In the present study, we investigated its cardiovascular toxic effect in anesthetized rat in vivo and in isolated Langendorff rat heart, In anesthetized rat model, carbofuran (10 mg/kg) significantly reduced heart rate, and transiently increased blood pressure. In isolated rat heart, carbofuran (10) caused a significant depression in the left ventricular developed pressure (LVDP), indicating contractile dysfunction by carbofuran. Carbofuran (10) also decreased coronary flow rate (CFR) in isolated heart, indicating carbofuran-induced coronary dysfunction. These results suggest that carbofuran can cause cardiac dysfunction in rat in vivo and vitro.
Keywords
blood pressureheartCarbofuran
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Full Text Link
Files in This Item:
739-745.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse