Carbofuran Induces Cardiovascular Dysfunction in Rat
횐쥐의 심혈관 기능에 대한 carbofuran의 독성작용
정, 이숙; 이, 수환; 백, 은주; 문, 창규; 문, 창현
Yakhakhoe chi, 45(6):739-745, 2001
Yakhakhoe chi; Journal of the Pharmaceutical Society of Korea; 약학회지
Of all pesticides, carbamates are known to be most common, since alternatives such as organophosphates have long lifetime and are extremely toxic to produce a delayed neurotoxic effect. Although a number of studies about toxicity of carbofuran, a most widely used carbamate, have been reported, its cardiovascular toxicity has not yet been studied. In the present study, we investigated its cardiovascular toxic effect in anesthetized rat in vivo and in isolated Langendorff rat heart, In anesthetized rat model, carbofuran (10 mg/kg) significantly reduced heart rate, and transiently increased blood pressure. In isolated rat heart, carbofuran (10) caused a significant depression in the left ventricular developed pressure (LVDP), indicating contractile dysfunction by carbofuran. Carbofuran (10) also decreased coronary flow rate (CFR) in isolated heart, indicating carbofuran-induced coronary dysfunction. These results suggest that carbofuran can cause cardiac dysfunction in rat in vivo and vitro.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :2,783,181
Total Download :1,135,328
Today View :1,154
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.