165 440

Cited 0 times in

Inhibitory Activities of Natural Products on Lipopolysaccharide Induced Prostaglandin Production in Mouse Macrophages

Other Title
리포폴리사카라이드에 의해 유도되는 대식세포의 프로스타글란딘 생합성을 저해하는 천연물의 탐색
Authors
노, 민수; 하, 준용; 이, 창훈; 이, 우영; 이, 수환; 이, 정준
Citation
Yakhakhoe chi, 42(6):558-566, 1998
Journal Title
Yakhakhoe chi; Journal of the Pharmaceutical Society of Korea; 약학회지
ISSN
0377-9556
Abstract
Two isoforms of cyclooxygenase (COX) have been identified - COX-1, which is constitutively expressed in most tissues, and the inducible form, COX-2, of which expression is induced by inflammatory signals and mitogens. It has been considered that the benificial effects of NSAIDs are due to the inhibition of COX-2 activity and the side effects are from the inhibition of COX-1 activity. There-fore, it is essential to develop selective COX-2 inhibitor for developing new GI-tolerable NSAIDs. To discover new leads for developing selective COX-2 inhibitors, three-hundred extracts of natural pro-ducts were primarily screened with the system of prostaglandin accumulation in LPS-stimulated mouse peritoneal macrophages. To identify whether these inhibitory activities of crude extracts on the accumulation of prostaglandins were derived from direct action against COX-2, the effects of selected extracts on exogenous arachidonic acid-derived production of prostaglandin by LPS-stimulated macrophages were determined. Among them, 5 methanol extracts of natural products, such as Zingiberis Rhizoma, Alpinae Officinarum Rhizoma, Caryophilli Flos, Scutellariae Radix, Dalbergia ordorifera, inhibited more than 70% of the prostaglandin production in LPS-stimulated mouse peritoneal macrophages at a concentration of 1 μg/ml.
Keywords
Prostaglandinscyclooxygenase-2macrophagenatural products
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Full Text Link
Files in This Item:
558-566.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse